In silico Design, Synthesis, and Screening of Novel Deoxyhypusine Synthase Inhibitors Targeting HIV‐1 Replication
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Summary
A designed compound that showed dose‐dependent inhibition of DHS in vitro, as well as suppression of HIV replication in cell cultures and exhibited no cytotoxic effects at active concentrations represents a promising starting point for the development of new drug candidates to specifically interfere with DHS activity.
- Type
- article
- Published
- 2014-05-01
- Cited by
- 13
- References
- 68
- OpenAlex
- https://openalex.org/W24616161
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6223160
Keywords
Movie theater, Humanities, Art, Art history
References
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- Host factors exploited by retroviruses
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- Conformational Sampling for Large-Scale Virtual Screening: Accuracy versus Ensemble Size
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- Synthesis of 2,3-Disubstituted Indoles via Palladium-Catalyzed Annulation of Internal Alkynes
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- The reduction of indoles and related compounds.
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- Towards an Integrated Description of Hydrogen Bonding and Dehydration: Decreasing False Positives in Virtual Screening with the HYDE Scoring Function
- NAOMI: On the Almost Trivial Task of Reading Molecules from Different File formats
- Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy.
Cited by
- In silico modeling of small molecules and design of eIF-5A activation inhibitors
- Biological Relevance and Therapeutic Potential of the Hypusine Modification System*
- Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial
- Hypusination of eIF5A as a Target for Antiviral Therapy
- Synthesis and properties of poly(benzoxazole imide)s derived from two isomeric diamines containing a benzoxazole moiety
- Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
- New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase
- Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney
- Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
- eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
- Viral codon optimization on SARS‐CoV‐2 Spike boosts immunity in the development of COVID‐19 mRNA vaccines
- Unveiling EIF5A2: A Multifaceted Player in Cellular Regulation, Tumorigenesis and Drug Resistance.
- Polyamine Metabolism and the DHPS/eIF5A Hypusination Axis: From Metabolic Reprogramming to a Therapeutic Achilles’ Heel in Melanoma
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