Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2
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Summary
Differences between MKK1 and MKK2 in sites of phosphorylation by proline-directed protein kinases predict differences in feedback regulation.
- Type
- article
- Published
- 1993-08-01
- Cited by
- 148
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W8393135
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36572782
Keywords
Coping (psychology), Psychology, Developmental psychology, Cognitive psychology, Social psychology
References
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- cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
- The amino acid sequence of a mammalian MAP kinase kinase.
- Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol.
- Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.
- Signal transduction within the nucleus by mitogen-activated protein kinase.
- Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
- Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.
- Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase.
- MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.
- Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.
- Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils.
- Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
- Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor.
- Nuclear localization and regulation of erk- and rsk-encoded protein kinases
- Inhibition of v-src-induced transformation by a GTPase-activating protein
- ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
- ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK.
- A template for the protein kinase family.
- Use of eukaryotic expression technology in the functional analysis of cloned genes.
Cited by
- Participation of Reactive Oxygen Species in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Kinase Activation Pathway (*)
- Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells
- Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells.
- Signal transduction through MAP kinase cascades.
- Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
- Isotype-specific functions of Raf kinases.
- Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways1
- Stress activated MAPKs in plants
- Assay of MEK kinases.
- The role of signal transduction pathways in drug and radiation resistance.
- Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases.
- The MAP kinase cascade.
- Natriuretic Peptides’ Metabolic Targets for Treatment of Cancer
- Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?
- Preparation and use of semiintact mammalian cells for analysis of signal transduction.
- Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts
- Regulation of epidermal growth factor receptor signaling during oxidative stress
- Mitogen-activated protein [MAP] kinase pathways in plants: versatile signaling tools.
- MAP kinases in mitogenesis and development.
- Phosphorylation of the Human Cytomegalovirus 86-Kilodalton Immediate-Early Protein IE2
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