Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticity
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Summary
The functional plasticity of NK-22 cells is demonstrated, which may allow flexible responses to different pathogens, and it is found that NK- 22 cells released the B-cell survival factor, B- cell activating factor belonging to the TNF family (BAFF), suggesting a potential role of NK -22 cells in promoting B–mediated mucosal immunity.
- Type
- article
- Published
- 2010-06-01
- Cited by
- 359
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W1982840915
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205248969
Keywords
Cytokine, Interleukin 12, Cell biology, Interleukin 21, Secretion
References
- IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+ cell subsets from Id2-dependent precursors
- Dual Role of Melanoma Cell Adhesion Molecule (MCAM)/CD146 in Lymphocyte Endothelium Interaction: MCAM/CD146 Promotes Rolling via Microvilli Induction in Lymphocyte and Is an Endothelial Adhesion Receptor1
- RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells
- Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
- Cracking the BAFF code
- Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?
- The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
- IL-22: A critical mediator in mucosal host defense
- Interleukin 23 receptor is essential for terminal differentiation of effector T helper type 17 cells in vivo
- Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity.
- A human NK cell subset provides an innate source of IL-22 for mucosal immunity
- Late Developmental Plasticity in the T Helper 17 Lineage
- Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells
- Human natural killer cell development
- Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22.
- Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin
- The functional plasticity of T cell subsets
- Critical regulation of early Th17 cell differentiation by IL-1 signaling
- Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice.
- IL‐22 and inflammation: Leukin' through a glass onion
Cited by
- Innate lymphoid cells: emerging insights in development, lineage relationships, and function.
- Transcription factors controlling development and function of innate lymphoid cells.
- Immune Modules Shared by Innate Lymphoid Cells and T Cells
- Extracellular proliferating cell nuclear antigen as a marker and therapeutic target for cancer stem cells
- Induction of innate immune responses by plant-derived procyanidins and polysaccharides
- Inducers & Organizers in Human Fetal and Adult Lymphoid Tissues : the characterization of RORC+ innate lymphoid cells and RANKL+ marginal reticular cells in human fetal and adult secondary lymphoid organs
- Innate lymphoid cells in immunity and disease.
- Polymorphisme du gène NCR3/NKp30 et variabilité de la fonction des cellules Natural Killer humaines
- Study of the activation of peripheral blood and cord blood natural killer cells
- Innate lymphoid cells — how did we miss them?
- Control of epithelial cell function by interleukin‐22‐producing RORγt+ innate lymphoid cells
- Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.
- Characteristics of innate lymphoid cells (ILCs) and their role in immunological disorders (an update).
- Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice
- Innate Lymphoid Cells Groups 1 and 3 in the Epithelial Compartment of Functional Human Intestinal Allografts
- Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.
- Innate lymphoid cells in inflammatory bowel diseases.
- Natural killer cell receptor-expressing innate lymphocytes: more than just NK cells
- AHR and the Transcriptional Regulation of Type-17/22 ILC
- Multifaceted roles of interleukin-7 signaling for the development and function of innate lymphoid cells.
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