Human natural killer cell development
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Summary
An overview of recent findings onNK cell development in humans is provided and the strongest evidence stems from the observation that the newly described stages of human NK cell development are naturally and selectively enriched within lymph nodes and tonsils compared with blood and BM.
- Type
- review
- Published
- 2006-12-01
- Cited by
- 526
- References
- 206
- OpenAlex
- https://openalex.org/W2026884886
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46441731
Keywords
Biology, Immunology, Context (archaeology), Lymphopoiesis, Natural killer cell
References
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- A role for lymphotoxin in the acquisition of Ly49 receptors during NK cell development
- Single adult human CD34(+)/Lin-/CD38(-) progenitors give rise to natural killer cells, B-lineage cells, dendritic cells, and myeloid cells.
- Differentiation of natural killer (NK) cells from human primitive marrow progenitors in a stroma-based long-term culture system: identification of a CD34+7+ NK progenitor.
- Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent.
- Final steps of natural killer cell maturation: a model for type 1–type 2 differentiation?
- Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.
- Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation.
- The hare and the tortoise: an embryonic haematopoietic race
- Organogenesis of peripheral lymphoid organs
- Comparative studies of human FcRIII-positive and negative natural killer cells.
- Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment.
- Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors.
- IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells.
- Costimulatory signals are required for optimal proliferation of human natural killer cells.
- Selective elimination of marrow precursors with the bone-seeking isotope 89Sr: implications for hemopoiesis, lymphopoiesis, viral leukemogenesis and infection.
- CD16- CD56+ natural killer cells after bone marrow transplantation.
- Genesis of human oncolytic natural killer cells from primitive CD34+CD33- bone marrow progenitors.
- CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation1
- The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.
Cited by
- Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell-depleted allogeneic hematopoietic cell transplantation.
- Proteolytic Activation of the Cytotoxic Phenotype during Human NK Cell Development1
- IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+ cell subsets from Id2-dependent precursors
- Molecular mechanisms influencing NK cell development: implications for NK cell malignancies.
- Insights into NK cell biology from human genetics and disease associations
- Metabolic Regulation of Natural Killer Cell IFN-γ Production
- Humanized immune system (HIS) mice as a tool to study human NK cell development.
- NK/DC crosstalk in anti-viral response.
- Impact of physical activity on immune function and inflammation in the elderly
- KIR/HLA: genetic clues for a role of NK cells in the control of HIV.
- Etude des mécanismes régulateurs des cellules NK : rôle de la molécule PD-1 et de la prostaglandine E2 (PGE2)
- In vitro increased natural killer cell activity of metastatic melanoma patients with interferon-α alone as opposed to its combination with 13-cis retinoic acid is associated with modulation of NKG2D and CD161 activating receptor expression.
- Charakterisierung antileukämischer NK-Zell-Klone von gesunden Spendern und Patienten nach allogener Stammzelltransplantation
- Natural killer cells in HIV-1 infection: a double-edged sword.
- Development of natural killer cells from hematopoietic stem cells.
- Investigating the role of Epstein-Barr virus in the pathogenesis of NK and T cell lymphoproliferations
- In vitro determination and functional maturation of natural killer cells from umbilical cord blood progenitor cells
- Practical NK cell phenotyping and variability in healthy adults
- Contribution à l'étude des mécanismes de l'alloréactivité des cellules Natural Killer humaines
- Cellules NK et fièvres hémorragiques virales : étude de leur rôle dans la mise en place des réponses immunes et dans la pathogenèse lors de l'infection par les virus Lassa et Ebola
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