Late Developmental Plasticity in the T Helper 17 Lineage
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Summary
A model of late Th17 developmental plasticity with implications for auto-immunity and host defense is supported with implications for auto-immunity and host defense.
- Type
- article
- Published
- 2009-01-16
- Cited by
- 1,122
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011882192
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205410946
Keywords
Biology, STAT4, Autoimmunity, T helper cell, Interleukin 23
References
- Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System1
- IL-17 family cytokines and the expanding diversity of effector T cell lineages.
- IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination1
- Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1
- Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells.
- A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1
- Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).
- IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.
- Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.
- Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12.
- Differentiation and function of Th17 T cells.
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
- Th17 cell differentiation: the long and winding road.
- Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
- Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice.
- IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
- IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
- Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
- IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
- A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
Cited by
- Wolbachia endosymbiont of Onchocerca volvulus: driver of immunopathology and target for therapy
- T-Helping Colitis.
- Th17 cells: positive or negative role in tumor?
- Hypoxia induces T Helper 17 cell upregulation in cultured peripheral blood mononuclear cells from chronic stage patients of severe cerebral infarction
- Role of the Gut Microbiota in the Development and Function of Lymphoid Cells
- Regulation of IL-17A Production Is Distinct from IL-17F in a Primary Human Cell Co-culture Model of T Cell-Mediated B Cell Activation
- IL-1 and T Helper Immune Responses
- Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production
- Sensitivity and Resistance to Regulation by IL-4 in Th17 Cells: Molecular Mechanisms and Significance in Autoimmune Disease.
- Model Checking to Assess T-Helper Cell Plasticity
- Immune Modules Shared by Innate Lymphoid Cells and T Cells
- Chronic graft-versus-host disease: disease biology and novel therapeutic strategies.
- Physiological and pathophysiological functions of SOCE in the immune system
- The good and the bad of neuroinflammation in multiple sclerosis.
- Characterisation of cytokine expression in early synovitis and established rheumatoid arthritis
- Humoral response towards high density lipoprotein : a new mechanism for atherogenesis
- Plasticity of immunological synapses.
- Regulation of T cell responses by the surface receptor Tim-3
- Efecto del péptido intestinal vasoactivo sobre los linfocitos Th17 y su relación con otras subpoblaciones th: implicación en enfermedades autoinmunes-inflamatorias
- Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
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