Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies
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Summary
Interactions of Toll-like receptors (TLRs) with COX enzymes in vivo are reported and COX-2 inhibition could provide a novel anti-viral therapeutic strategy.
- Type
- article
- Published
- 2013-08-23
- Cited by
- 49
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W1981956953
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15965546
Keywords
TLR2, TLR7, TLR3, TLR9, Cytokine
References
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- Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
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- Prostaglandin E2 is a negative regulator on human plasmacytoid dendritic cells
- Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins
- Contrasting Effects of Cyclooxygenase-1 (COX-1) and COX-2 Deficiency on the Host Response to Influenza A Viral Infection1
- The Effect of HIV and HPV Co-infection on Cervical COX-2 Expression and Systemic Prostaglandin E2 Levels
- Structure of the human cyclo-oxygenase-2 gene.
- Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
Cited by
- Lactobacillus rhamnosus GG and Bifidobacterium longum Attenuate Lung Injury and Inflammatory Response in Experimental Sepsis
- Multi-constituent synergism is responsible for anti-inflammatory effect of Azadirachta indica leaf extract
- Reversible Suppression of Cyclooxygenase 2 (COX-2) Expression In Vivo by Inducible RNA Interference
- Effects of Wharton’s jelly-derived mesenchymal stem cells on neonatal neutrophils
- Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways
- RESPOSTA FEBRIL INDUZIDA POR DIFERENTES PADRÕES MOLECULARES ASSOCIADOS A PATÓGENOS EM RATOS
- Cyclooxygenase 2: its regulation, role and impact in airway inflammation
- Inflammatory and oxidative stress in rotavirus infection.
- Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability
- Mechanisms of immunosuppression by mesenchymal stromal cells: a review with a focus on molecules
- Gene expression profiles associated with lymphocystis disease virus (LCDV) in experimentally infected Senegalese sole (Solea senegalensis)
- Cytotoxic Vibrio T3SS1 Rewires Host Gene Expression to Subvert Cell Death Signaling and Activate Cell Survival Networks
- The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo
- Cancer Pain Management: Comprehensive Assessment and Nonopioid Analgesics, Part 1
- Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities.
- Protective effect of aspirin treatment on mouse behavior in the acute phase of experimental infection with Trypanosoma cruzi
- Expression and Activity of COX-1 and COX-2 in Acanthamoeba sp.-Infected Lungs According to the Host Immunological Status
- Expression and function of TLR4‐ induced B1R bradykinin receptor on cardiac fibroblasts
- Characteristics of NSAID‐induced hypersensitivity reactions in childhood
- Transcriptomic analysis of differential gene expression reveals an increase in COX2 levels during in vitro canine herpesvirus infection
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