Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.
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Summary
Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid, however, they develop severe nephropathy and are susceptible to peritonitis.
- Type
- article
- Published
- 1995-11-03
- Cited by
- 1,117
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W2083651943
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16207743
Keywords
Biology, Gene isoform, Cyclooxygenase, Inflammation, Isozyme
References
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- TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue.
- Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells.
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- Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells.
- Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase.
- Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo.
- Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.
- Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.
- Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.
- Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity.
- Drugs which inhibit prostaglandin biosynthesis.
- Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis.
Cited by
- Cyclooxygenase-2 is essential for normal recovery from 5-fluorouracil-induced myelotoxicity in mice.
- Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts.
- Non‐steroidal anti‐inflammatory drugs with different cyclooxygenase inhibitory profiles that prevent aberrant crypt foci formation but vary in acute gastrotoxicity in a rat model 1
- Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept.
- Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin.
- COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production.
- Developmental changes in cyclo‐oxygenase mRNA induction by hypoxia in rat kidney
- Peripheral Nerve Dysfunction in Experimental Diabetes Is Mediated by Cyclooxygenase-2 and Oxidative Stress
- Arachidonic acid pathways in nociception.
- Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury.
- Interactions between NO, CO and an endothelium‐derived hyperpolarizing factor (EDHF) in maintaining patency of the ductus arteriosus in the mouse
- The Spatiotemporal Role of COX-2 in Osteogenic and Chondrogenic Differentiation of Periosteum-Derived Mesenchymal Progenitors in Fracture Repair
- Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice.
- Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2
- Reflections on flurbiprofen eyedrops
- The regulation of cyclooxygenase-1 and -2 in knockout cells and cyclooxygenase and fever in knockout mice.
- Other transgenic mutation assays: Development of a novel mouse tk+/− embryonic stem cell line for use in mutagenicity studies
- Talking to the Brain at the Blood-Brain Barrier through Inflammation-Induced Prostaglandin E2
- Complement C5b-9-mediated arachidonic acid metabolism in glomerular epithelial cells : role of cyclooxygenase-1 and -2.
- An accessory role for ceramide in interleukin-1β induced prostaglandin synthesis
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