Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children
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Summary
Results suggest that SNPs of G1544C and A1651G might be act as susceptibility genetic factors of asthma.
- Type
- article
- Published
- 2009-07-01
- Cited by
- 25
- References
- 24
- OpenAlex
- https://openalex.org/W2093214227
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12991727
Keywords
Single-nucleotide polymorphism, Linkage disequilibrium, Haplotype, Genotype, Allele
References
- STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation.
- Asthma severity and genetics in Taiwan.
- Role of interleukin-13 in cancer, pulmonary fibrosis, and other T(H)2-type diseases.
- Possible Novel Receptor for PGD2 on Human Bronchial Epithelial Cells
- A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q
- Evidence for asthma susceptibility genes on chromosome 11 in an African-American population
- Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse 1
- Elevated Allergen-Induced IL-13 Secretion Predicts IgE Elevation in Children Ages 2–5 Years
- Multipoint linkage disequilibrium mapping for complex diseases
- Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
- Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA)
- Interleukin‐13 in asthma pathogenesis
- Genetic Impact of Functional Single Nucleotide Polymorphisms in the 3′-UTR Region of the Chemoattractant Receptor Expressed on Th2 Cells (CRTH2) Gene on Asthma and Atopy in a Japanese Population
- Reassessing the Th2 cytokine basis of asthma.
- Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation.
- Identification of Indole Derivatives Exclusively Interfering with a G Protein-Independent Signaling Pathway of the Prostaglandin D2 Receptor CRTH2
- Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview
- Complete inhibition of allergic airway inflammation and remodelling in quadruple IL‐4/5/9/13−/− mice
- Biology and Therapeutic Potential of the Interleukin-4/Interleukin-13 Signaling Pathway in Asthma
- IL-13: a promising therapeutic target for bronchial asthma.
Cited by
- Association between gap junction protein-alpha 8 polymorphisms and age-related cataract
- Pharmacogenetics of the G protein-coupled receptors.
- Asthma research in China: A five‐year review
- Novel CRTH2 antagonists: a review of patents from 2006 to 2009
- The mRNA level of Charcot–Leyden crystal protein/galectin-10 is a marker for CRTH2 activation in human whole blood in vitro
- Attempted Replication of 50 Reported Asthma Risk Genes Identifies a SNP in RAD50 as Associated with Childhood Atopic Asthma
- Genetic variability in CRTH2 polymorphism increases eotaxin‐2 levels in patients with aspirin exacerbated respiratory disease
- Genetic variation in CRTh2 influences development of allergic phenotypes
- The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation following epicutaneous antigen challenge
- The Bcl I single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR/NR3C1 promoter in patients with bronchial asthma: pilot study
- Cytokine gene polymorphism and asthma susceptibility, progress and control level
- Association of ADAM33 polymorphisms with childhood asthma in a northern Chinese population.
- Expression analysis of asthma candidate genes during human and murine lung development
- The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2
- Current and future biomarkers in allergic asthma
- Genetic Polymorphism of Prostanoid Receptors, CRTH2 and TBXA2R in Aspirin Hypersensitivity
- A global perspective in asthma: from phenotype to endotype.
- Preclinical safety profile of a depleting antibody against CRTh2 for asthma: Well tolerated despite unexpected CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa
- Depletion of major pathogenic cells in asthma by targeting CRTh2.
- Pharmacogenomics of Prostaglandin and Leukotriene Receptors
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