Structure and function of the spleen
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Summary
The spleen enables it to remove older erythrocytes from the circulation and leads to the efficient removal of blood-borne microorganisms and cellular debris, which makes it the most important organ for antibacterial and antifungal immune reactivity.
- Type
- review
- Published
- 2005-08-01
- Cited by
- 2,243
- References
- 128
- Access
- Open access
- OpenAlex
- https://openalex.org/W1981160000
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3258595
Keywords
Spleen, Immune system, Function (biology), Compartment (ship), Biology
References
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- Impaired human antibody response to the thymus-independent antigen, DNP-Ficoll, after splenectomy. Implications for post-splenectomy infections.
- Identification of the haemoglobin scavenger receptor
- Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase
- Localization of Marginal Zone Macrophages Is Regulated by C-C Chemokine Ligands 21/191
- Constitutive Expression of CCR7 Directs Effector CD8 T Cells into the Splenic White Pulp and Impairs Functional Activity1
- Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.
- B Cells Control the Migration of a Subset of Dendritic Cells into B Cell Follicles Via CXC Chemokine Ligand 13 in a Lymphotoxin-Dependent Fashion1
- Sialic acid binding receptors (siglecs) expressed by macrophages
- Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines1
- TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes.
- Regulation of secondary lymphoid organ development by the nuclear factor‐κB signal transduction pathway
Cited by
- The role of CC-chemokine receptor-like 2 in the B cell response
- Expression of Immunoglobulin Receptors with Distinctive Features Indicating Antigen Selection by Marginal Zone B Cells from Human Spleen
- Artificial engineering of secondary lymphoid organs.
- Dendritic cell immunobiology in relation to liver transplant outcome.
- Staphylococcus aureus infection after splenectomy and splenic autotransplantation in BALB/c mice
- Imaging Listeria monocytogenes infection in vivo.
- Pathophysiology of tissue fluid accumulation in inflammation
- A role for macrophage migration inhibitory factor in protective immunity against Aspergillus fumigatus.
- Making a Difference: Monocyte Heterogeneity in Cardiovascular Disease
- The role of visfatin on the regulation of inflammation and apoptosis in the spleen of LPS-treated rats
- Identification of signalling cascades involved in red blood cell shrinkage and vesiculation
- The role of erythrocyte CD47 in intracerebral hematoma clearance
- Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology
- The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion.
- Human Circulating and Tissue-Resident CD56bright Natural Killer Cell Populations
- A hyperspectral method to assay the microphysiological fates of nanomaterials in histological samples
- The cardiovascular hormone ANP interferes with LPS-induced early inflammatory pathways in vitro and in vivo
- Use of erythrocyte indicators of health and condition in vertebrate ecophysiology: a review and appraisal
- Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats
- Altered Gene Response to Aflatoxin B1 in the Spleens of Susceptible and Resistant Turkeys
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