Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats
Explore this paper's citation graph
Summary
The data indicate that the systemic delivery of Peptide5 is unlikely to cause any off-target or adverse effects and may thus be a safe treatment option for traumatic SCI.
- Type
- article
- Published
- 2017-07-19
- Cited by
- 16
- References
- 88
- Access
- Open access
- OpenAlex
- https://openalex.org/W2736462209
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24427221
Keywords
Systemic administration, Medicine, Spinal cord, Spinal cord injury, Anesthesia
References
- A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury.
- Development and selection of marginal zone B cells
- Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+
- Novel mechanism for hyper-reflexia and spasticity
- Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?
- Changes in blood–brain barrier permeability to large and small molecules following traumatic brain injury in mice
- ATP and glutamate released via astroglial connexin43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
- Connexin 43 Antisense Therapy Modulates Connexin Expression and Wound Repair in Nitrogen Mustard Injured Mouse Skin
- Gap-junction-mediated propagation and amplification of cell injury
- Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia
- Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43.
- LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain.
- Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion.
- Connexin Channels, Connexin Mimetic Peptides and ATP Release
- Theca-derived BMP4 and BMP7 down-regulate connexin43 expression and decrease gap junction intercellular communication activity in immortalized human granulosa cells.
- Gap junction proteins and their role in spinal cord injury
- Sustained intravitreal delivery of connexin43 mimetic peptide by poly(D,L-lactide-co-glycolide) acid micro- and nanoparticles--Closing the gap in retinal ischaemia.
- Structure and function of the spleen
- Connexin hemichannel blockade is neuroprotective after, but not during, global cerebral ischemia in near-term fetal sheep.
- A key role for connexin hemichannels in spreading ischemic brain injury.
Cited by
- The Connexin Mimetic Peptide Gap27 and Cx43-Knockdown Reveal Differential Roles for Connexin43 in Wound Closure Events in Skin Model Systems
- Therapeutic strategies targeting connexins
- Connexin Hemichannels in Astrocytes: Role in CNS Disorders
- The Role of Connexin and Pannexin Channels in Perinatal Brain Injury and Inflammation
- Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases
- Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem
- Synthesis and biological evaluation of S-lipidated lipopeptides of a connexin 43 channel inhibitory peptide.
- Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells
- Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration
- Mechanisms of Connexin Mimetic Peptides
- Mechanisms of Connexin Regulating Peptides
- The Potential Role of Connexins in the Pathogenesis of Atherosclerosis
- Boldine modulates glial transcription and functional recovery in a murine model of contusion spinal cord injury
- Boldine modulates glial transcription and functional recovery in a murine model of contusion spinal cord injury
- Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α 2 β 1 Binding in TGF β 1-Evoked Renal Tubular Epithelial Cells
Related papers
- Gastrointestinal Complications in Spinal Cord Injury
- Spinal cord injury immediately decreases anesthetic requirements in rats
- Extrinsic and intrinsic factors controlling axonal regeneration after spinal cord injury
- Whole body measurements using near-infrared spectroscopy in a rat spinal cord contusion injury model
- Diffusion Tensor Imaging of the Central Nervous System Following an Injury to the Spinal Cord and Cell Transplant
- LPA receptor expression in the central nervous system in health and following injury
- Effect of spinal cord injury on the permeability of the blood-brain and blood-spinal cord barriers to the neurotropin PACAP.