Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling
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Summary
It is shown that osteosarcoma cell lines SaOS-2 and U2OS show invasive properties in vitro by activating Wnt5a/Ror2 signaling in a cell-autonomous manner, and that constitutively active Wnt 5a/ Ror 2 signaling confers invasive properties on osteosARcoma cells in acell-aut autonomous manner.
- Type
- article
- Published
- 2009-09-10
- Cited by
- 186
- References
- 35
- OpenAlex
- https://openalex.org/W1980416049
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7167296
Keywords
Invadopodia, Biology, Osteosarcoma, WNT5A, Signal transduction
References
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Cited by
- Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma
- Wnt/beta-catenin signaling in liver homeostasis and regeneration
- Wnt signaling in osteosarcoma.
- Genomic Instability of Osteosarcoma Cell Lines in Culture: Impact on the Prediction of Metastasis Relevant Genes
- Shikonin inhibits invasiveness of osteosarcoma through MMP13 suppression
- Postnatal positioning of neuronal precursors in the dorso-medial limbic cortex : a potential involvement of Wnt signaling pathways
- Role of DNA methylation in WNT5A promoter B expression in osteosarcoma cells
- The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis
- Evidence of functional distinction between WNT5A Isoform A and Isoform B in osteosarcoma cells
- Critical role of Wnt5a–Ror2 signaling in motility and invasiveness of carcinoma cells following Snail‐mediated epithelial–mesenchymal transition
- Functional Crosstalk Between WNT Signaling and Tyrosine Kinase Signaling in Cancer.
- Wnt Pathway in Osteosarcoma, from Oncogenic to Therapeutic
- Knockdown of receptor tyrosine kinase-like orphan receptor 2 inhibits cell proliferation and colony formation in osteosarcoma cells by inducing arrest in cell cycle progression.
- Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer
- Stable Genetic Alterations of β‐Catenin and ROR2 Regulate the Wnt Pathway, Affect the Fate of MSCs
- Mechanisms of Wnt signaling: from embryonic stem cells to dopaminergic neurons
- Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma.
- Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE.
- WNT5A is a Key Regulator of the Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties in Human Gastric Carcinoma Cells
- WNT signalling pathways as therapeutic targets in cancer
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