Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
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Summary
This study shows for the first time that a single Wnt ligand can initiate discrete signaling pathways through the activation of two distinct receptors, and proposes a model wherein receptor context dictates Wnt signaling output.
- Type
- article
- Published
- 2006-04-01
- Cited by
- 1,270
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W2009684443
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52804986
Keywords
Wnt signaling pathway, Frizzled, LRP6, Biology, LRP5
References
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- The Caenorhabditis elegans Ror RTK CAM-1 Inhibits EGL-20/Wnt Signaling in Cell Migration
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Cited by
- Do factors secreted from synovial fibroblasts affect the differentiation of C2C12 cells
- Expression of Wnt5a and its downstream effector &bgr;-catenin in uveal melanoma
- The Wnt-5a–Derived Hexapeptide Foxy-5 Inhibits Breast Cancer Metastasis In vivo by Targeting Cell Motility
- An orphan nuclear receptor finds a home.
- Canonical Wnt3a Modulates Intracellular Calcium and Enhances Excitatory Neurotransmission in Hippocampal Neurons*
- Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.
- p21-Activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression
- Emphasizing the role of Wnt5a protein expression to predict favorable outcome after radical prostatectomy in patients with low-grade prostate cancer
- Wnt Secretion and Gradient Formation
- Molecular mechanisms of sex determination and testis differentiation
- Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity
- Both Canonical and Non-Canonical Wnt Signaling Independently Promote Stem Cell Growth in Mammospheres
- Gpr177-mediated Wnt Signaling Is Required for Secondary Palate Development
- Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma
- Wnt-expressing cells in the intestines: guides for tissue remodeling
- Higher expression of WNT5A protein in oral squamous cell carcinoma compared with dysplasia and oral mucosa with a normal appearance
- Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer
- The Kidney and Planar Cell Polarity
- Isolation and application of bioactive Wnt proteins.
- Epithelial Cell Shape Changes During Lung Branching Morphogenesis: The Role of Wnt/Fzd2 signaling in directing new branch formation
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