Hypoxia: A key regulator of angiogenesis in cancer

Keywords

Angiogenesis, Hypoxia (environmental), Regulator, HIF1A, Cancer research

References

• Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites.Jian Li, Nicholas W. Shworak, Michael Simons — 2002
• Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide.Hideo Kimura, Alessandro Weisz, Yukiko Kurashima — 2000
• Mechanisms of angiogenesis and arteriogenesisPeter Carmeliet — 2000
• Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.Christine Blancher, John W. Moore, Naomi Robertson — 2001
• Prolonged tumor dormancy by prevention of neovascularization in the vitreous.Steven Brem, Henry Brem, Judah Folkman — 1976
• Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degenerationBert Oosthuyse, Lieve Moons, Erik Storkebaum — 2001
• Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21waf1/cip1, and ErythropoietinKhalequz Zaman, Hoon Ryu, David H. Hall — 1999
• Critical role for NF‐κB‐induced JunB in VEGF regulation and tumor angiogenesisDirk Schmidt, Björn Textor, Oliver Tobias Pein — 2007
• A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.Masatsugu Ema, Shin-ichiro Taya, Noboru Yokotani — 1997
• Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesisHiroaki Nozawa, Christopher Chiu, Douglas Hanahan — 2006
• Age-Related Changes in Parathyroid Hormone-Related Protein and Vascular Endothelial Growth Factor in Human Osteoblastic CellsPedro Martínez Martínez, Pedro Esbrit, Ana Moreno Rodrigo — 2002
• Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes.Frank Jung, Lisa A. Palmer, Nan Zhou — 2000
• An essential role for p300/CBP in the cellular response to hypoxia.Zoltàn Arany, Eric Huang, Richard Eckner — 1996
• FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.David Lando, Daniel J. Peet, Jeffrey J. Gorman — 2002
• A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma.Bikul Das, Herman Yeger, Rika Tsuchida — 2005
• Malignant Glioma Physiology: Cellular Response to Hypoxia and Its Role in Tumor ProgressionDaniel J. Brat, Timothy B. Mapstone — 2003
• Tumor angiogenesis: therapeutic implications.Louis M. Sherwood, Edith E. Parris, Judah Folkman — 1971
• Human Neural Stem Cells Over-Expressing VEGF Provide Neuroprotection, Angiogenesis and Functional Recovery in Mouse Stroke ModelHong J. Lee, Kwang S. Kim, In H. Park — 2007
• Induction of angiogenesis during the transition from hyperplasia to neoplasiaJ Folkman, Karol Watson, Donald E. Ingber — 1989
• Identification of MAPK Phosphorylation Sites and Their Role in the Localization and Activity of Hypoxia-inducible Factor-1α*Ilias Mylonis, Georgia Chachami, Martina Samiotaki — 2006

Cited by

• Correlative Imaging of Hypoxia and Angiogenesis in OncologyCatherine Applefeld Olson — 2008
• Rôle des facteurs de transcription E2F2 et ID3 dans la progression tumorale et intérêt du ciblage de l'aminopeptidase N/CD13 dans le traitement du cancer colique humainManon Voegelin — 2012
• PET Monitoring of Therapy Response in Head and Neck Squamous Cell CarcinomaHeiko Schöder, Matthew G. Fury, Nancy Y. Lee — 2009
• Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7.Dragoş-Victor Anghel — 2009
• Novel monoclonal antibodies specific for CTLD-SSC and sialomucin domains of endosialin, a mural cell marker of tumor vasculature.万里 木本 — 2012
• Specific protein markers for stem cell cross-talk with neighboring cells in the environment.Maria Grazia Vinardi — 2013
• Cancer cells remodel themselves and vasculature to overcome the endothelial barrierValeria Pancioli, Ping Lü, Filippo Catani — 2014
• Investigations into the Ulnar Response to Mechanical Stimuli Activating Lamellar and Woven Bone FormationJennifer A. McKenzie — 2009
• Implication de l’Insulin-like Growth Factor (IGF-I), secrété par le microenvironnement tumoral, dans la survie et la chimiorésistance des cellules cancéreusesNadia Benabbou — 2012
• Mort cellulaire induite par des radiations ionisantes dans des tumeurs humaines radiorésistantes : étude, in vitro et in vivo, des mécanismes impliqués dans son induction par différents types de rayonnements et modulation pharmacologiqueAnaïs Altmeyer — 2010
• The Hypoxic Tumor Microenvironment: A Driving Force for Breast Cancer ProgressionGregg L. Semenza — 2015
• Mutationsanalyse und Charakterisierung von transkriptionellen Targetgenen des Metastasierungs-induzierenden Gens MACC1F. Schmid — 2013
• Rôle du treillis Mgat5/galectine-3 et de la cavéoline-1 dans la fibrillogenèse de la fibronectine et la migration cellulaire : Lien avec la dynamique des points focaux d'adhésionJacky G. Goetz — 2007
• Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphomaSatoshi Kambayashi, Masaya Igase, Kosuke Kobayashi — 2015
• BONE MARROW-DERIVED CELLS IN ANGIOGENESIS AND CANCERSusanna Lauttia — 2014
• Investigation of the anti-breast cancer efficacy and mechanisms of disulfiramPeng Liu — 2015
• The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma PathogenesisAdam Myszczyszyn, Anna M. Czarnecka, Damian Matak — 2015
• Hypoxia, therapeutic resistance, and sphingosine 1-phosphate.Olivier Cuvillier, Isabelle Ader, Pierre Bouquerel — 2013
• Vascular permeability—the essentialsLena Claesson‐Welsh — 2015
• NADPH Oxidases as Regulators of Tumor Angiogenesis: Current and Emerging ConceptsSanja Coso, Ian Harrison, Craig B. Harrison — 2012

Related papers

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• von Hippel–Lindau tumor suppressor (VHL); hypoxia-inducible factor 1 (HIF1A; HIF1)2009
• Hypoxia-inducible factor prolyl hydroxylase (HIF-PH; EGLN); hypoxia-inducible factor 1α (HIF1A; HIF1α)2013
• Mouse model of von Hippel-Lindau renal cancer driven by hypoxia-inducible factor 1α (HIF1A; HIF1α)2011
• Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell CarcinomaRaju R. Raval, Kah Weng Lau, Maxine Tran — 2005
• von Hippel-Lindau Tumor Suppressor Protein and Hypoxia-Inducible Factor in Kidney CancerMindy A. Maynard, Michael Ohh — 2004
• Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylationChloe-Anne Martinez, Yannasittha Jiramongkol, Neha Bal — 2022