Genomic imprinting: mother maintains methylation marks.
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Summary
A DNA methyltransferase has been identified that plays a role in maintaining the methylation status of imprinted genes, Interestingly, although expressed in the unfertilised egg, this enzyme functions only during one round of replication in the eight-cell embryo.
- Type
- article
- Published
- 2001-07-10
- Cited by
- 36
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W1978471190
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15175078
Keywords
Biology, Genomic imprinting, Imprinting (psychology), DNA methylation, Methylation
References
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- Cell lineage-specific undermethylation of mouse repetitive DNA
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
- DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe.
- DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
- Embryogenesis: Demethylation of the zygotic paternal genome
- DNA methylation in health and disease
- Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.
- Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.
- The DNA methyltransferases of mammals.
- Chromosome methylation patterns during mammalian preimplantation development.
- X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation.
- Genomic imprinting: parental influence on the genome
- Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting.
- The foundation of two distinct cell lineages within the mouse morula.
- Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development.
Cited by
- Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?
- Mechanisms regulating imprinted genes in clusters.
- Epigenetic reprogramming during early development in mammals.
- 2 Detection of antisense to igf2r (air) rna in cattle
- Unearthing the roles of imprinted genes in the placenta.
- Germ cell specification and pluripotency in mammals: a perspective from early embryogenesis
- Placental Dysfunction and Fetal Programming: The Importance of Placental Size, Shape, Histopathology, and Molecular Composition
- The role of imprinted genes in humans.
- Gametes and Embryo Epigenetic Reprogramming Affect Developmental Outcome: Implication for Assisted Reproductive Technologies
- The elusive Dnmt1 and its role during early development
- Imprinting and the Epigenetic Asymmetry Between Parental Genomes
- Suboptimal in vitro culture conditions: an epigenetic origin of long‐term health effects
- Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
- Intracytoplasmic Sperm Injection-An Assisted Reproduction Technique That Should Make Us Cautious About Imprinting Deregulation
- Evaluation of In Vitro Cultured Rat Oocytes, from Different Strains, by Spindle Morphology and Maturation-Promoting-Factor Activity Combined with Nuclear-Transfer Experiments
- Epigenetics in women's health care.
- Epigenetic risks related to assisted reproductive technologies: risk analysis and epigenetic inheritance.
- Dynamic regulation of DNA methyltransferases in human oocytes and preimplantation embryos after assisted reproductive technologies.
- A physiological, rather than a superovulated, post‐implantation environment can attenuate the compromising effect of assisted reproductive techniques on gene expression in developing mice embryos
- The role of imprinted genes in humans
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- Heat stress causes aberrant DNA methylation of H19 and Igf-2r in mouse blastocysts.
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- DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.
- Abnormal expression of DNA methyltransferases and genomic imprinting in cloned goat fibroblasts
- Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development.