Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development.
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Summary
Stage- and tissue-specific global demethylation and remethylation occurring during embryonic development are shown and it is proposed that much of the methylation observed in somatic tissues acts to stabilize and reinforce prior events that regulate the activity of specific genes, chromosome domains or the X chromosome.
- Type
- article
- Published
- 1987-03-01
- Cited by
- 1,120
- References
- 37
- OpenAlex
- https://openalex.org/W2175849508
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2386414
Keywords
Biology, DNA methylation, Somatic cell, Epigenetics, Methylation
References
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Cited by
- Gene expression during preimplantation mouse development.
- Eukaryotic DNA methyltransferases – structure and function
- DNA methylation in genomic imprinting.
- A mammalian protein with specific demethylase activity for mCpG DNA
- Phänotypische Variation des Genotyps: Retrotransposone als epigenetische Mediatoren?
- Monitoring methylation changes in cancer.
- Limited demethylation leaves mosaic‐type methylation states in cloned bovine pre‐implantation embryos
- Epi-alleles in plants: inheritance of epigenetic information over generations.
- Epigenetic reprogramming in mammalian nuclear transfer.
- Of microbes, mice and man.
- The constant variation: DNA methylation changes during preimplantation development
- High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.
- Modulation of embryo-forming capacity in culture through the expression of Brassica genes involved in the regulation of the shoot apical meristem
- Epstein-barr virus transformed DNA as a source of false positive findings in methylation studies of psychiatric conditions.
- Epigenetic mechanisms and cancer: An interface between the environment and the genome
- Hematopoietic stem cell development: an epigenetic journey.
- Epigenetic control of gene expression.
- Evolutionary impacts of DNA methylation on vertebrate genomes
- Reprogramming the genome: role of the cell cycle.
- X chromosome inactivation and DNA methylation.
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