Fitting a Mixture Model By Expectation Maximization To Discover Motifs In Biopolymer
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Summary
The algorithm described in this paper discovers one or more motifs in a collection of DNA or protein sequences by using the technique of expectation maximization to fit a two-component finite mixture model to the set of sequences.
- Type
- article
- Published
- 1994-01-01
- Cited by
- 5,526
- References
- 19
- OpenAlex
- https://openalex.org/W1592870802
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7117788
Keywords
Motif (music), Expectation–maximization algorithm, Computer science, Sequence motif, Classifier (UML)
References
- Estimation and Hypothesis Testing in Finite Mixture Models
- Methods in Enzymology
- Novel repetitive sequence motifs in the alpha and beta subunits of prenyl-protein transferases and homology of the alpha subunit to the MAD2 gene product of yeast.
- Using Dirichlet Mixture Priors to Derive Hidden Markov Models for Protein Families
- Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment.
- An expectation maximization (EM) algorithm for the identification and characterization of common sites in unaligned biopolymer sequences
- Pattern classification and scene analysis
- Identification of consensus patterns in unaligned DNA sequences known to be functionally related
- The Statistical Analysis of Discrete Data
- Analysis of conserved domains and sequence motifs in cellular regulatory proteins and locus control regions using new software tools for multiple alignment and visualization.
- Profile Analysis
- John wiley & sons.
- The Statistical Analysis of Discrete Data.
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- Sensor-based Knowledge Discovery from a Large Quantity of Situational Variables
- Family pairwise search with embedded motif models
- Extraction for Frequent Sequential Patterns with Minimum Varaible-Wildcard Regions
- Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation.
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- Site-directed mutagenesis of the active site of diacylglycerol kinase alpha: calcium and phosphatidylserine stimulate enzyme activity via distinct mechanisms.
- Designing, performing, and interpreting a microarray-based gene expression study.
- Computational Biology in Acute Myeloid Leukemia with CEBPA Abnormalities
- The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response.
- Identification of genes responsive to intracellular zinc depletion in the human colon adenocarcinoma cell line HT-29.
- Map-based cloning of a fertility restorer gene, Rf-1, in rice (Oryza sativa L.).
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