Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?
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Summary
The most critical roadblocks and concerns for clinical RNAi transition, delivery, and safety are reviewed and emerging solutions are highlighted and novel therapeutic RNAi-based concepts are discussed.
- Type
- article
- Published
- 2007-12-03
- Cited by
- 157
- References
- 94
- Access
- Open access
- OpenAlex
- https://openalex.org/W18060021
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25368343
Keywords
Ancient history, History, Classics
References
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- Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
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- Chemical modification: the key to clinical application of RNA interference?
- A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference
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- RNAi in Combination with a Ribozyme and TAR Decoy for Treatment of HIV Infection in Hematopoietic Cell Gene Therapy
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- Efficient gene transfer of HIV-1-specific short hairpin RNA into human lymphocytic cells using recombinant adeno-associated virus vectors.
Cited by
- Silencing phospholipid scramblase 1 expression by RNA interference in colorectal cancer and metastatic liver cancer.
- Role of MAP4K4 Signaling in Adipocyte and Macrophage Derived Inflammation: A Dissertation
- Ribonucleotide reductase as a target to control apicomplexan diseases.
- UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE), a master regulator of sialic acid synthesis
- siRNA Targeting of Thymidylate Synthase, Thymidine Kinase 1 and Thymidine Kinase 2 as an Anticancer Therapy: A Combinatorial RNAi Approach
- Target Validation to Biomarker Development
- Mitogen activated protein kinases in renal fibrosis.
- RNA Interference Mediated Suppression of Tn-Caspase-1 as a means of investigating apoptosis and improving recombinant protein production in Trichoplusia ni cells
- Abolishing multidrug resistance in cultured lung cancer cells with RNA interference
- Investigation of Transfection Using Silica-coated Cupric Oxide Nanowires
- Gene therapy in animal models of autosomal dominant retinitis pigmentosa
- Transgenic RNAi applications in the mouse.
- Efficient and targeted delivery of siRNA in vivo
- Review article: RNA interference – potential therapeutic applications for the gastroenterologist
- Protein-protein and protein-small-molecule inhibitor interactions in the measles virus replication complex
- Silencing Early Viral Replication in Macrophages and Dendritic Cells Effectively Suppresses Flavivirus Encephalitis
- Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery
- Systemic RNAi Delivery to the Muscles of ROSA26 Mice Reduces lacZ Expression
- Screening siRNAs targeting a novel gene (HA117) and the development of a derivative recombinant adenovirus delivery system
- MicroRNA-Mediated Myostatin Silencing in Caprine Fetal Fibroblasts
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