C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
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Summary
Data suggest that RAP1 is a central regulator of both telomere and chromosome stability and define a C-terminal domain that, while dispensable for viability, is required for these telomeric functions.
- Type
- article
- Published
- 1992-11-01
- Cited by
- 264
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1958533176
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8765017
Keywords
Telomere-binding protein, Biology, Telomere, Saccharomyces cerevisiae, Genetics
References
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- Vanadate-resistant mutants of Saccharomyces cerevisiae show alterations in protein phosphorylation and growth control
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- Genetic control of chromosome length in yeast.
- Saccharomyces telomeres assume a non-nucleosomal chromatin structure.
- RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability.
- Telomere terminal transferase activity in the hypotrichous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules.
- DNA sequences of telomeres maintained in yeast
- Cloning yeast telomeres on linear plasmid vectors.
Cited by
- Identification and Characterization of Novel Sir3/MeCP2-Chromatin Interactions
- TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae
- Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains.
- Rap1 affects the length and heterogeneity of human telomeres.
- TERRA: Long Noncoding RNA at Eukaryotic Telomeres.
- Epigenetics in Saccharomyces cerevisiae.
- Telomerase and malignant transformation.
- Rice proteins that bind single-stranded G-rich telomere DNA
- Telomere structural dynamics in genome integrity control and carcinogenesis.
- The role of telomeres and chromosome linearity in the survival of DNA damage
- Novel functions of Rif1 at telomeres and double strand breaks in S. cerevisiae
- Trafic intracellulaire de l’ARN de la télomérase chezSaccharomyces cerevisiæ : relation entre biogénèse de latélomérase et homéostasie des télomères
- Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication
- Regulation of telomere movement by telomere chromatin structure.
- The Role of HeT-A and TART Retrotransposons in Drosophila Telomere Capping
- Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions
- Intermediate filament proteins: cytoskeletal elements with gene-regulatory function?
- Contribution of histones to nucleosome stability, DNA accessibility, and higher order chromatin structures in yeast
- Telomere length homeostasis in the yeast "Saccharomyces cerevisiae"
- Rap1p and telomere length regulation in yeast.
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