Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
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Summary
Blocking angiopoietin-2 (ANG2), a TIE2 ligand and angiogenic factor expressed by activated endothelial cells (ECs), regresses the tumor vasculature and inhibits progression of late-stage, metastatic MMTV-PyMT mammary carcinomas and RIP1-Tag2 pancreatic insulinomas.
- Type
- article
- Published
- 2011-04-12
- Cited by
- 636
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977587080
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5198510
Keywords
Angiopoietin receptor, Angiogenesis, Cancer research, Neovascularization, Downregulation and upregulation
References
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- Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.
- Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis.
- Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
- The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies.
- Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
- Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
- Modes of resistance to anti-angiogenic therapy
- A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships.
- Macrophages, innate immunity and cancer: balance, tolerance, and diversity.
- Recruitment of myeloid but not endothelial precursor cells facilitates tumor re-growth after local irradiation
- Regulation of tie2 expression by angiopoietin--potential feedback system.
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.
- Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
- Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction.
- Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands
Cited by
- Angiopoietins in angiogenesis.
- Endothelial cell‐derived angiopoietin‐2 is a therapeutic target in treatment‐naive and bevacizumab‐resistant glioblastoma
- VEGF, ANGPT1, ANGPT2, and MMP-9 expression in the autologous hematopoietic stem cell transplantation and its impact on the time to engraftment
- The emerging roles of macrophages in cancer metastasis and response to chemotherapy
- Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery
- Tumor-associated myeloid cells: diversity and therapeutic targeting
- The role of inflammatory cells in angiogenesis in multiple myeloma.
- Role of macrophages in cardiac homeostasis and repair following myocardial infarction
- ROLE OF MACROPHAGES IN ADAPTIVE RESISTANCE TO ANTI-VEGF THERAPY
- Hypoxia Inducible Factors in Cancer and Inflammation
- Abl Family Kinases Regulate Endothelial Function
- Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice
- Expression du récepteur Frizzled7 par les macrophages : rôle dans le contrôle de l’angiogenèse via la régulation de la polarisation macrophagique
- Macrophage heterogeneity in neovascularization
- Macrophages: Biology and Role in the Pathology of Diseases
- VEGFR3 and Notch signaling in angiogenesis
- Venous thromboembolism in patients with cancer undertaking chemotherapy
- Classical monocytes from patients with pancreatic ductal adenocarcinoma exhibit a significantly altered transcriptome profile compared with healthy volunteers
- Analysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression
- Modifications of the mouse bone marrow microenvironment favor angiogenesis and correlate with disease progression from asymptomatic to symptomatic multiple myeloma
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