Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells
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Summary
It is described that doxorbicin induces apoptosis via the CD95/CD95–L system in human leukemia T–cell lines and this finding provides a new molecular insight into resistance and sensitivity toward chemotherapy in malignancies.
- Type
- article
- Published
- 1996-05-01
- Cited by
- 1,085
- References
- 23
- OpenAlex
- https://openalex.org/W1977499961
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44811884
Keywords
Fas receptor, Apoptosis, Jurkat cells, Cytotoxic T cell, Fas ligand
References
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- Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
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- Abrogation of adriamycin toxicity in vivo by cycloheximide.
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- The Role of APO‐1‐Mediated Apoptosis in the Immune System
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- Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
- Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia.
- Activation interferes with the APO-1 pathway in mature human T cells.
Cited by
- Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
- Doxorubicin‐induced apoptosis in human T‐cell leukemia is mediated by caspase‐3 activation in a Fas‐independent way
- The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
- Two distinct modes of oncoprotein expression during apoptosis resistance in vincristine and daunorubicin multidrug-resistant HL60 cells.
- Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1.
- Acute and Chronic Smooth Muscle Cell Apoptosis After Mechanical Vascular Injury Can Occur Independently of the Fas-Death Pathway
- Antiproliferative‐Antiinflammatory Effects of Methotrexate and Sex Hormones on Cultured Differentiating Myeloid Monocytic Cells (THP‐1)
- The effect of the Fas/FasL pathway during chemotherapeutic drug-induced apoptosis of leukameic cells
- Identification of drug‐regulated genes in osteosarcoma cells
- Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor
- CD95 ligand induces motility and invasiveness of apoptosis‐resistant tumor cells
- In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling.
- Recognizing death: liver phagocytosis of apoptotic cells.
- Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL.
- Doxorubicin Exerts Cytotoxic Effects through Cell Cycle Arrest and Fas-Mediated Cell Death
- NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
- Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60
- Quercetin enhances the effects of 5-fluorouracil-mediated growth inhibition and apoptosis of esophageal cancer cells by inhibiting NF-κB.
- Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitro.
- Anthracycline Use for Early Stage Breast Cancer in the Modern Era: a Review
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