Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

Hiroyasu Sakuraba, Hiroki Mizukami, Nobuo Yagihashi, Ryuichi Wada, C. Hanyu · Diabetologia · 2002

Summary

Japanese Type II diabetic patients show a reduction of beta-cell mass and evidence of increased oxidative stress-related tissue damage that is correlated with the extent of the beta- cell lesions.

Type: article
Published: 2002-01-01
Cited by: 694
References: 0
Access: Open access
DOI: https://doi.org/10.1007/s125-002-8248-z
PubMed: https://pubmed.ncbi.nlm.nih.gov/11845227/
OpenAlex: https://openalex.org/W2005754586
Semantic Scholar: https://api.semanticscholar.org/CorpusID:22192714

Keywords

Islet, Endocrinology, Oxidative stress, Internal medicine, Immunostaining

References

Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and effluxKeiji Yoshida, Jun Hirokawa, S. Tagami — 1995
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implicationsRoger H. Unger — 1995
Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humansY. Stefan, Lelio Orci, F. Malaisse-Lagae — 1982
In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243Tetsuro Kobayashi, K Nakanishi, H. Nakase — 1997

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Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

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