Normal and Cancer-Related Functions of the p160 Steroid Receptor Coactivator (SRC) Family
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Summary
The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptionAL co-activators.
- Type
- review
- Published
- 2009-09-01
- Cited by
- 499
- References
- 196
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977027014
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10314800
Keywords
Carcinogenesis, Nuclear receptor, Cancer research, Prostate cancer, Nuclear receptor coactivator 1
References
- SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.
- Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue
- Steroid receptor coactivator-3, a homolog of Taiman that controls cell migration in the Drosophila ovary, regulates migration of human ovarian cancer cells.
- SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas.
- Progesterone-binding Components of Chick Oviduct
- TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors.
- A signature motif in transcriptional co-activators mediates binding to nuclear receptors
- Progesterone-binding components of chick oviduct. 3. Chromatin acceptor sites.
- A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia.
- The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
- Steroid receptor coactivator-1 is a histone acetyltransferase
- Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer.
- Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen.
- SRC-3 is required for prostate cancer cell proliferation and survival.
- Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate response.
- The Coactivator p/CIP/SRC-3 Facilitates Retinoic Acid Receptor Signaling via Recruitment of GCN5*
- Steroid Receptor Coactivator-1 Coactivates Activating Protein-1-mediated Transactivations through Interaction with the c-Jun and c-Fos Subunits*
- Androgen Receptor-interacting Protein 3 and Other PIAS Proteins Cooperate with Glucocorticoid Receptor-interacting Protein 1 in Steroid Receptor-dependent Signaling*
- An Isoform of the Coactivator AIB1 That Increases Hormone and Growth Factor Sensitivity Is Overexpressed in Breast Cancer*
- The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.
Cited by
- ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells
- Altered histone modifications in cancer.
- Crafting the Brain – Role of Histone Acetyltransferases in Neural Development and Disease
- Lysine residues 639 and 673 of mouse Ncoa3 are ubiquitination sites for the regulation of its stability.
- Gene Fusions in Soft Tissue Tumors: Recurrent and Overlapping Pathogenetic Themes
- Mechanisms of resistance in castration-resistant prostate cancer (CRPC)
- Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3.
- Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner
- THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS
- Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation.
- An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation
- Identification de co-régulateurs impliqués dans la réponse transcriptionnelle induite par les récepteurs AhR et ER[alpha]
- Etude fonctionnelle et évolutive de la voie de l'acide rétinoique et de la phosphorylation des récepteurs chez le poisson zèbre
- Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype
- The regulatory role of osteoblasts in castration-resistant growth of prostate cancer
- NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription
- Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/β-Catenin Signaling*
- Autocrine and paracrine regulation of endothelial cell function by F-Prostanoid receptor signalling.
- Critical Components of the Pluripotency Network Are Targets for the p300/CBP Interacting Protein (p/CIP) in Embryonic Stem Cells
- Estrogen receptor co-regulators as prognostic and predictive markers of endocrine therapy in early breast cancer: the role of SMRT and p160 family
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