Altered histone modifications in cancer.
Explore this paper's citation graph
Summary
Correlative evidence supports the idea that these patterns are distorted in malignancy on both a genome-wide and a discrete gene loci level and insight from understanding these processes addresses the challenge of targeted epigenetic therapies in cancer.
- Type
- review
- Published
- 2013-01-01
- Cited by
- 39
- References
- 188
- OpenAlex
- https://openalex.org/W24646763
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24750497
Keywords
Epigenetics, Biology, Histone, Genetics, Epigenetic regulation of neurogenesis
References
- Human Histone Demethylase LSD1 Reads the Histone Code*
- Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
- Histone modifications as markers of cancer prognosis: a cellular view
- All four core histone N‐termini contain sequences required for the repression of basal transcription in yeast.
- 19-nor-26,27-bishomo-vitamin D3 analogs: a unique class of potent inhibitors of proliferation of prostate, breast, and hematopoietic cancer cells.
- Regulatory diversity among metazoan co-activator complexes
- Role of the histone deacetylase complex in acute promyelocytic leukaemia
- Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen.
- Short chain fatty acids and colon cancer.
- Histone variants — ancient wrap artists of the epigenome
- A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
- Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism in the Chemosensitivity of Tumour Cells
- Normal and Cancer-Related Functions of the p160 Steroid Receptor Coactivator (SRC) Family
- Warburg effect revisited: merger of biochemistry and molecular biology.
- Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
- Genetics and epigenetics: stability and plasticity during cellular differentiation.
- Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
- New nomenclature for chromatin-modifying enzymes.
- NCOA3, a new fusion partner for MOZ/MYST3 in M5 acute myeloid leukemia
- Electrostatic interactions with histone tails may bend linker DNA in chromatin
Cited by
- Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
- The organization, regulation and functions of genes in the pericentric heterochromatin of the Drosophila melanogaster third chromosome
- Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets
- HDAC inhibitors and immunotherapy; a double edged sword?
- Deregulation of histone-modifying enzymes and chromatin structure modifiers contributes to glioma development.
- Functional Role of G9a Histone Methyltransferase in Cancer
- The Interactions of microRNA and Epigenetic Modifications in Prostate Cancer
- Epigenetic Hierarchy within the MAGEA1 Cancer-Germline Gene: Promoter DNA Methylation Dictates Local Histone Modifications
- Transcriptional and Epigenetic Regulation of KIF14 Overexpression in Ovarian Cancer
- DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11
- The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells
- Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators
- Bromodomains and Their Pharmacological Inhibitors
- Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases
- Sequence-Level Mechanisms of Human Epigenome Evolution
- Epigenetic biomarkers in laboratory diagnostics: emerging approaches and opportunities
- Targeting Deregulated Epigenetic Control in Cancer: Cancer Epigenomics as a Platform for Risk Assessment, Early Detection, Targeted Therapy and Potential for Relapse
- Nicotine induces alteration of H3K27 demethylase UTX in kidney cancer cell
- The functional diversity of protein lysine methylation
- Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies.
Related papers
- Epigenomics and epigenetic therapy of cancer.
- Histone methylation patterns in human breast cancer
- Disorders of histone methylation: Molecular basis and clinical syndromes
- Role of histone methylation in skin cancers: Histone methylation-modifying enzymes as a new class of targets for skin cancer treatment.
- Histone methyltransferases: novel targets for tumor and developmental defects.
- The molecular landscape of histone lysine methyltransferases and demethylases in non-small cell lung cancer
- Epigenetic interplay of histone modifications and DNA methylation mediated by HDA6
- Fine-tuning AKT kinase activity through direct lysine methylation
- DZNep Is a Global Histone Methylation Inhibitor that Reactivates Developmental Genes Not Silenced by DNA Methylation