Effects of acute hyperinsulinemia on testosterone serum concentrations in adult obese and normal-weight men.
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Summary
Findings are consistent with the hypothesis that insulin may regulate testosterone blood levels also in male subjects, and whether these effects are primarily due to increased hormone secretion or reduced clearance needs to be investigated.
- Type
- article
- Published
- 1997-05-01
- Cited by
- 84
- References
- 23
- OpenAlex
- https://openalex.org/W1976801771
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22608494
Keywords
Hyperinsulinemia, Internal medicine, Endocrinology, Testosterone (patch), Androgen
References
- Insulin augmentation of testosterone production in a primary culture of rat testicular cells.
- The effects of experimental hyperinsulinemia on steroid secretion, ovarian [125I]insulin binding, and ovarian [125I]insulin-like growth-factor I binding in the rat.
- Sex hormone-binding globulin: a marker for hyperinsulinemia and/or insulin resistance?
- The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans.
- Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men.
- Measurement of steroid hormones in plasma by isocratic high performance liquid chromatography coupled to radioimmunoassay.
- Characterization of insulin and insulin-like growth factor I receptors of purified Leydig cells and their role in steroidogenesis in primary culture: a comparative study.
- The gonadotropic function of insulin.
- Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.
- Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men.
- The relationship between aromatase activity and body fat distribution.
- Mild Hypogonadotropic hypogonadism in obese men.
- Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome.
- Total Body Fat Content and Fat Topography Are Associated Differently With In Vivo Glucose Metabolism in Nonobese and Obese Nondiabetic Women
- Effect of obesity and body fat distribution on sex hormones and insulin in men.
- Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome.
- Glucose clamp technique: a method for quantifying insulin secretion and resistance.
- Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels.
- INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT *
- Low serum testosterone and sex-hormone-binding-globulin in massively obese men.
Cited by
- Testosterone and atherosclerosis.
- Vigorous Physical Activity is Associated with Regular Aerobic Exercise-Induced Increased Serum Testosterone Levels in Overweight/Obese Men
- Androgens in Health and Disease
- Testicular function during adolescence in boys with type 1 diabetes mellitus (T1D): absence of hypogonadism and differences in endocrine profile at the beginning and end of puberty
- Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction
- Novel insights in SHBG regulation and clinical implications.
- Gonadal hormones and gonadotrophins in healthy males beyond forty years.
- Prediabetes and associated disorders
- Insulin gene polymorphism and premature male pattern baldness in the general population.
- Elevated serum dehydroepiandrosterone sulphate level correlates with increased risk for metabolic syndrome in the elderly men
- Functional state of the hypothalamic-pituitary-gonadal axis in diabetes mellitus
- The genetics of androgenetic alopecia.
- Serum testosterone level and related metabolic factors in men over 70 years old
- Migration is associated with lower total, but not free testosterone levels in South Asian men
- Screening for hypogonadism in diabetes 2008/9: results from the Cheshire Primary Care cohort.
- Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis.
- Hypogonadotrophic hypogonadism in type 2 diabetes
- Glucose ingestion acutely lowers pulsatile LH and basal testosterone secretion in men.
- Determinants of sexual dysfunction among clinically diagnosed diabetic patients
- The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction.
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