Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.
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Summary
It is concluded that insulin and PRL inhibit SHBG production and confirmed that T4, T, and E2 stimulate SH BG production in vitro, suggesting that insulin or PRL may be important factors in the regulation of SHBGProduction in vivo.
- Type
- article
- Published
- 1988-09-01
- Cited by
- 736
- References
- 24
- OpenAlex
- https://openalex.org/W2036203117
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25190940
Keywords
Sex hormone-binding globulin, Internal medicine, Endocrinology, Insulin, Hormone
References
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- Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia.
- Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration.
- Hormonal control of SBP in human hepatoma cells.
- Plasma sex hormone-binding globulin levels decrease during the second decade of life irrespective of pubertal status.
- ALTERED PULSATILE SECRETION OF LUTEINIZING HORMONE IN HYPOGONADAL MEN WITH HYPERPROLACTINAEMIA
- Estrogen memory effect in human hepatocytes during repeated cell division without hormone.
- Radioimmunoassays specific for the tertiary and primary structures of thyroxine-binding globulin (TBG): measurement of denatured TBG in serum.
- The relationship of sex hormones to hyperinsulinemia and hyperglycemia.
- Response of serum testosterone and its precursor steroids, SHBG and CBG to anabolic steroid and testosterone self-administration in man.
- SEX‐HORMONE‐BINDING GLOBULIN
- BASAL AND STIMULATED INSULIN LEVELS RISE WITH ADVANCING PUBERTY
- Characterization of a monoclonal antibody to human sex hormone binding globulin
- Prolactinomas, testosterone-binding globulin, and androgen metabolism.
- Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.
- Hormonal influences on the secretion of steroid-binding proteins by a human hepatoma-derived cell line.
- Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography.
- Fasting plasma glucose and insulin levels and their relationship to cardiovascular risk factors in children: Bogalusa Heart Study.
- Relationship of androgenic activity to splanchnic insulin metabolism and peripheral glucose utilization in premenopausal women.
- Insulin resistance and diminished glucose tolerance in powerlifters ingesting anabolic steroids.
Cited by
- Growth factors in the ovary
- Body measurements, estrogen availability and the risk of human breast cancer: A case‐control study
- Effect of testosterone on regulation of the level of sex steroid-binding protein mRNA in monkey (Macaca fascicularis) liver.
- Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
- Thyroxine withdrawal is accompanied by decreased circulating levels of insulin-like growth factor-binding protein-1 in thyroidectomized patients.
- Ovarian electrocauterization causes LH‐regulated but not insulin‐regulated endocrine changes
- A case of partial face-sparing lipodystrophy combining features of generalized lipodystrophy.
- Insulin increases histomorphometric indices of bone formation In vivo
- Expression of sex hormone-binding globulin exon VII splicing variant mRNA in human uterine endometrium.
- Effects of insulin-like growth factor I (IGF-I) therapy on body composition and insulin resistance in IGF-I gene deletion.
- Visceral fat accumulation as a risk factor for prostate cancer.
- Hypothalamic-Pituitary Axis and Peripheral Tissue Responses to TRH Stimulation and Liothyronine Suppression Tests in Normal Subjects Evaluated by Current Methods
- Benign Prostatic Hyperplasia: Does Lifestyle Play a Role?
- Association of Testosterone and Sex Hormone–Binding Globulin With Metabolic Syndrome and Insulin Resistance in Men
- Obesity and cancer, a case for insulin signaling
- The changing role of the clinical laboratory in the investigation of polycystic ovarian syndrome.
- Sex hormone binding globulin, but not testosterone, is associated with the metabolic syndrome in overweight and obese women with polycystic ovary syndrome
- Structure, function, and regulation of androgen-binding protein/sex hormone-binding globulin.
- Obesity and infertility
- Metabolische und Genotypische Charakteristika bei Frauen mit polyzystischem Ovar Syndrom
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