Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome.
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Summary
It is shown that insulin can directly alter peripheral sex hormone levels independent of changes in gonadotropin release in insulin-resistent PCO women, arguing against a simple, direct causal relationship between hyperinsulinemia and hyperandrogenism in PCO.
- Type
- article
- Published
- 1989-01-01
- Cited by
- 201
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2079672855
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21787190
Keywords
Endocrinology, Internal medicine, Polycystic ovary, Insulin, Hyperinsulinemia
References
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- Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia.
- Insulin receptors are widely distributed in the central nervous system of the rat
- Insulin and C-Peptide Levels in Obese Patients with Polycystic Ovaries
- Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing hormone agonist.
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- Characterization of insulin-like growth factor receptors in rat anterior pituitary, hypothalamus, and brain.
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- Simple method for the determination of plasma corticoids.
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- Primary amenorrhea associated with hirsutism, acanthosis nigricans, dermoid cysts of the ovaries and a new type of insulin resistance.
- Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function.
Cited by
- Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome
- Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells.
- Study on the Differences of Endocrine and Metabolic Characteristics in Clinical Subtypes of PCOS
- Menstrual disorders in adolescents. Excess androgens and the polycystic ovary syndrome.
- Insulin resistance and fertility in polycystic ovary syndrome.
- Gonadotropin-releasing hormone pulses: regulators of gonadotropin synthesis and ovulatory cycles.
- Biennial review of infertility
- THE GENETICS OF INSULIN RESISTANCE IN FAMILIES WITH POLYCYSTIC OVARY SYNDROME
- Effect of non-esterified fatty acids on insulin resistance and cardiovascular risk in polycystic ovary syndrome
- Menstrual irregularity: a possible clinical marker of metabolic dysfunction in women with class III obesity
- Cortisol and the polycystic ovary syndrome
- Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.
- Reduction of dehydroepiandrosterone sulfate synthesis in women with polycystic ovary syndrome by human menopausal gonadotropin but not purified urinary follicle stimulating hormone: a comparative pilot study
- Hyperinsulinism and its interaction with hyperandrogenism in polycystic ovary syndrome.
- Hyperinsulinemia and circulating dehydroepiandrosterone sulfate in white and Mexican American women with polycystic ovary syndrome.
- Obesity Management in Women with Polycystic Ovary Syndrome
- The effect of sequential administration of octreotide alone and octreotide/growth hormone simultaneously on buserelin stimulated ovarian steroid secretion in women with polycystic ovary syndrome
- The role of insulin in ovarian size in patients with the polycystic ovary syndrome.
- Increased luteinizing hormone and alpha-subunit secretion in women with hyperandrogenic anovulation.
- The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.
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