Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
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Summary
The results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology.
- Type
- article
- Published
- 1999-11-18
- Cited by
- 1,299
- References
- 26
- OpenAlex
- https://openalex.org/W1677043489
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4411606
Keywords
Osteoprotegerin, Osteoclast, Bone remodeling, Inflammation, Arthritis
References
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- TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor
- Recent developments in the understanding of the pathophysiology of osteopetrosis.
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- RAG-1-deficient mice have no mature B and T lymphocytes.
- Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor
Cited by
- The role of T cells in osteoporosis, an update.
- Have the new drugs relieved the burden of the orthopedic surgeon?
- Serum measurement of osteoprotegerin--clinical relevance and potential applications.
- Features of mono‐ and multinucleated bone resorbing cells of the zebrafish Danio rerio and their contribution to skeletal development, remodeling, and growth
- Effect of cyclical intermittent etidronate therapy on circulating osteoprotegerin levels in patients with rheumatoid arthritis.
- Identification of RANKL in Osteolytic Lesions of the Facial Skeleton
- Bone loss in the spondyloarthropathies: role of osteoclast, RANKL, RANK and OPG in the spondyloarthropathies.
- How we got attached to Actinobacillus actinomycetemcomitans: A model for infectious diseases.
- High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes.
- Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis.
- Innate Immune-Like Function of Osteogenic Cells and Their Effects on Inflammatory Osteolysis
- T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ.
- T cells as key players for bone destruction in gouty arthritis?
- Expression of osteoprotegerin and receptor activator of nuclear factor κB ligand in root resorption induced by heavy force in rats
- Activation status of γδ T cells dictates their effect on osteoclast generation and bone resorption
- Anti-mouse RANKL Antibodies Inhibit Alveolar Bone Destruction in Periodontitis Model Mice.
- Immunoporosis: Immunology of Osteoporosis—Role of T Cells
- Targeting osteoporosis and rheumatoid arthritis by active vaccination against RANKL.
- RANKL inhibition: from mice to men (and women).
- TRANCE/RANKL in bone erosion in arthritis
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