Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments.
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Summary
Interference with the CD1d antigen presentation pathway represents an HIV-1 strategy to evade innate cellular immune responses and imply a role for the innate-likeCD1d-restricted NKT cells in the host defense against HIV- 1.
- Type
- article
- Published
- 2010-09-16
- Cited by
- 140
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W1976212425
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12635121
Keywords
CD1D, Endosome, Biology, Innate immune system, Cell biology
References
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- Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells1
- Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant V alpha 14-J alpha 281 TCR.
- CD1d Ligands: The Good, the Bad, and the Ugly1
- Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.
- A cell-free stock of simian-human immunodeficiency virus that causes AIDS in pig-tailed macaques has a limited number of amino acid substitutions in both SIVmac and HIV-1 regions of the genome and has offered cytotropism.
- Human CD1d–glycolipid tetramers generated by in vitro oxidative refolding chromatography
- Tenets of protection from progression to AIDS: lessons from the immune responses to HIV-2 infection
- NK T Cells Contribute to Expansion of CD8+ T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus
- HIV‐1 down‐regulates the expression of CD1d via Nef
- Severe functional impairment and elevated PD-1 expression in the CD1d-restricted NKT cells retained in chronic HIV-1 infection
- A novel gene of HIV-1, vpu, and its 16-kilodalton product.
- CD1 antigen presentation: how it works
- CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system.
- Tuning immune responses: diversity and adaptation of the immunological synapse
- Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
Cited by
- Mechanisms by which HIV-1 Nef disrupts the intracellular trafficking of host proteins
- Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1
- Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation
- Expression, purification and characterization of a full-length recombinant HIV-1 Vpu from inclusion bodies.
- Various plus unique: Viral protein U as a plurifunctional protein for HIV-1 replication
- Primates, Pathogens, and Evolution
- Étude du mécanisme d’augmentation de la relâche virale par la protéine Vpu du VIH-1
- Étude du rôle de la protéine Vpr du VIH-1 dans la modulation de la réponse immunitaire
- Mechanisms involved with immune hyperresponsiveness in newborns infected with respiratory viruses
- Regulatory B cells correlate with HIV disease progression
- NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 infection
- HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins
- Conservation Analysis of HIV-1 Protein Sequences Reveal Potential Drug Binding Sites: A Case of Viral Protein U and Protease
- Invariant NKT cells and CD1d in HIV-1 infection
- Nonclassical MHC-restricted invariant Vα6 T cells are critical for efficient early innate anti-viral immunity in the amphibian X. laevis
- HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3
- A virologist’s guide to hide and seek : evasion of innate immunity by primate lentiviruses
- Activation of human T cells by CD1 and self-lipids
- Vpu Protein: The Viroporin Encoded by HIV-1
- Impairment of CD1d-Restricted Natural Killer T Cells in Chronic HIV Type 1 Clade C Infection
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