Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1
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Summary
The crystal structure of a protein complex containing Vpu and BST2 cytoplasmic domains and the core of the clathrin adaptor protein complex 1 (AP1) reveals how Vpu hijacks the AP1-dependent membrane trafficking pathways to mistraffick BST2.
- Type
- book
- Published
- 2014-04-01
- Cited by
- 95
- References
- 97
- OpenAlex
- https://openalex.org/W24843023
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14679858
Keywords
Orthodontics, Medicine
References
- Direct internalization of cell-surface BST-2/tetherin by the HIV-1 accessory protein Vpu
- β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release
- SIV Nef Proteins Recruit the AP-2 Complex to Antagonize Tetherin and Facilitate Virion Release
- Implications of Nef: host cell interactions in viral persistence and progression to AIDS.
- NMR structural characterization of HIV‐1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles
- The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release
- Bst‐2/HM1.24 Is a Raft‐Associated Apical Membrane Protein with an Unusual Topology
- Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu
- Crystal structure of the clathrin adaptor protein 1 core.
- The Membrane-Proximal Tyrosine-Based Sorting Signal of Human Immunodeficiency Virus Type 1 gp41 Is Required for Optimal Viral Infectivity
- Viral infection and human disease--insights from minimotifs.
- Nef-mediated Clathrin-coated Pit Formation
- Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments.
- Vpu Binds Directly to Tetherin and Displaces It from Nascent Virions
- Innate Sensing of HIV-1 Assembly by Tetherin Induces NFκB-Dependent Proinflammatory Responses
- Disruption of the murine beta-adaptin gene leads to non-syndromic cleft palate
- HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A
- A novel gene of HIV-1, vpu, and its 16-kilodalton product.
- A Structural Explanation for the Recognition of Tyrosine-Based Endocytotic Signals
- Preservation of Tetherin and CD4 Counter-Activities in Circulating Vpu Alleles despite Extensive Sequence Variation within HIV-1 Infected Individuals
Cited by
- Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation
- HIV Suppression by Host Restriction Factors and Viral Immune Evasion
- Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge
- Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors
- HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins
- A virologist’s guide to hide and seek : evasion of innate immunity by primate lentiviruses
- Viral Membrane Channels: Role and Function in the Virus Life Cycle
- Vpu Protein: The Viroporin Encoded by HIV-1
- Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin
- Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly*
- Protein sorting at the trans-Golgi network.
- Forty Years of Clathrin‐coated Vesicles
- HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons
- Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1
- Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells
- Filamin A Is Involved in HIV-1 Vpu-mediated Evasion of Host Restriction by Modulating Tetherin Expression*
- A Review of Functional Motifs Utilized by Viruses
- Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence
- AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein.
- Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles
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