Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
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Summary
CD317 (also called BST2 or HM1), a membrane protein of previously unknown function, is identified as a tetherin andhibition of Vpu function and consequent mobilization of tetherin’s antiviral activity is a potential therapeutic strategy in HIV/AIDS.
- Type
- article
- Published
- 2008-01-24
- Cited by
- 1,967
- References
- 22
- Access
- Open access
- OpenAlex
- https://openalex.org/W2010458160
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4428848
Keywords
Tetherin, Retrovirus, Cell biology, Cell, Biology
References
- Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.
- The Vpu-regulated endocytosis of HIV-1 Gag is clathrin-independent.
- Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4
- A novel membrane antigen selectively expressed on terminally differentiated human B cells.
- Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein
- The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release
- Bst‐2/HM1.24 Is a Raft‐Associated Apical Membrane Protein with an Unusual Topology
- Functional role of human immunodeficiency virus type 1 vpu.
- Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.
- Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein.
- Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses.
- Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif
- Cell type‐dependence for Vpu function
- Quantitative Membrane Proteomics Reveals New Cellular Targets of Viral Immune Modulators
- Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production
- An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein.
- HIV-1 Vpu Promotes Release and Prevents Endocytosis of Nascent Retrovirus Particles from the Plasma Membrane
- Construction and Characterization of a Fluorescently Labeled Infectious Human Immunodeficiency Virus Type 1 Derivative
- Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly
- Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in the Naive Mouse, but a Promiscuous Cell Surface Antigen following IFN Stimulation1
Cited by
- Mechanisms by which HIV-1 Nef disrupts the intracellular trafficking of host proteins
- Development and application of non-integrating lentiviral vectors for gene therapy
- Rapid adversarial co-evolution of viruses and cellular restriction factors.
- Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy?
- An imperfect rule for the particle roost.
- Direct internalization of cell-surface BST-2/tetherin by the HIV-1 accessory protein Vpu
- β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release
- SIV Nef Proteins Recruit the AP-2 Complex to Antagonize Tetherin and Facilitate Virion Release
- Cellular Restriction Factors of Feline Immunodeficiency Virus
- Inhibition of virus-like particle release of Sendai virus and Nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2.
- Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1
- Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation
- Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase
- Structural determination of Virus protein U from HIV-1 by NMR in membrane environments
- No Love Lost Between Viruses and Interferons
- Function of Ubiquitin (Ub) Specific Protease 15 (USP15) in HIV-1 Replication and Viral Protein Degradation
- Various plus unique: Viral protein U as a plurifunctional protein for HIV-1 replication
- Human parainfluenza virus type 2 V protein inhibits induction of tetherin
- The Role of Caveolin 1 in HIV Infection and Pathogenesis
- The positive regulation of HIV-1 Vif mRNA splicing is required for efficient virus replication
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