Protein-tyrosine Phosphatase PTPN9 Negatively Regulates ErbB2 and Epidermal Growth Factor Receptor Signaling in Breast Cancer Cells*
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Summary
PTPN9 is suggested as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation and reducing invasion and MMP2 expression of MDA-MB-231 cells.
- Type
- article
- Published
- 2010-03-24
- Cited by
- 87
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1975706205
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35714188
Keywords
ERBB3, Phosphorylation, Epidermal growth factor receptor, Protein tyrosine phosphatase, Cancer research
References
- Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.
- Increased invasive potential and up-regulation of MMP-2 in MDA-MB-231 breast cancer cells expressing the beta3 integrin subunit.
- Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor.
- Identification of Major Binding Proteins and Substrates for the SH2-Containing Protein Tyrosine Phosphatase SHP-1 in Macrophages
- Up‐regulation of the protein tyrosine phosphatase SHP‐1 in human breast cancer and correlation with GRB2 expression
- Protein tyrosine phosphatases: from genes, to function, to disease
- ERBB receptors and cancer: the complexity of targeted inhibitors
- Activation of Src by Protein Tyrosine Phosphatase-1B is required for ErbB2 transformation of human breast epithelial cells
- Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum
- Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling
- Multiple ErbB-2/Neu Phosphorylation Sites Mediate Transformation through Distinct Effector Proteins*
- Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.
- STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor*
- Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.
- Regulation of Receptor Tyrosine Kinase Signaling by Protein Tyrosine Phosphatase-1B*
- Prognostic value of ERBB family mRNA expression in breast carcinomas
- PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells.
- Genes that mediate breast cancer metastasis to the brain
- c-erbB-2 in breast cancer: development of a clinically useful marker.
- Control of vesicle fusion by a tyrosine phosphatase
Cited by
- Protein tyrosine phosphatases in cancer: friends and foes!
- Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation
- Platelet miRNAs and cardiovascular diseases.
- DEVELOPMENTAL DEREGULATION AND TUMORIGENESIS INHIBITION IN 14-3-3ZETA KNOCKOUT MOUSE
- Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer
- PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop
- STAT5 is Activated by Epidermal Growth Factor and Induces Proliferation and Invasion in Trophoblastic Cells
- Crosstalk between kinases, phosphatases and miRNAs in cancer.
- A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes
- Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.
- Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells.
- The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes
- A Drosophila‐centric view of protein tyrosine phosphatases
- MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling
- Mining the Function of Protein Tyrosine Phosphatases in Health and Disease
- Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array.
- Microtubule inhibition causes epidermal growth factor receptor inactivation in oesophageal cancer cells.
- The regulatory roles of phosphatases in cancer
- Protein tyrosine phosphatases as novel targets in breast cancer therapy.
- EGFR negates the proliferative effect of oncogenic HER2 in MDA-MB-231 cells.
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