Activation of Src by Protein Tyrosine Phosphatase-1B is required for ErbB2 transformation of human breast epithelial cells
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Summary
Using human breast epithelial cells grown in a three-dimensional matrix, it is found that PTP1B, but not the closely related enzyme, T-cell PTP (TC-PTP), is required for ErbB2 transformation in vitro.
- Type
- article
- Published
- 2009-05-12
- Cited by
- 102
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W1980423373
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17067355
Keywords
Proto-oncogene tyrosine-protein kinase Src, Protein tyrosine phosphatase, Cancer research, Biology, Signal transduction
References
- Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity
- Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer.
- Increased expression of specific protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the neu oncogene.
- Differential activities of protein tyrosine phosphatases in intact cells.
- Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene.
- Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor.
- Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer.
- Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10.
- Expression of a protein tyrosine phosphatase in normal and v-src- transformed mouse 3T3 fibroblasts
- Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity
- The role of protein tyrosine phosphatase 1B in Ras signaling
- Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
- Role of SRC kinases in Neu-induced tumorigenesis: challenging the paradigm using Csk homologous kinase transgenic mice.
- Protein-tyrosine Phosphatase 1B Mediates the Effects of Insulin on the Actin Cytoskeleton in Immortalized Fibroblasts*
- Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity.
- Identification of Protein-tyrosine Phosphatase 1B as the Major Tyrosine Phosphatase Activity Capable of Dephosphorylating and Activating c-Src in Several Human Breast Cancer Cell Lines*
- Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok.
- Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets.
- Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP.
- Src family kinases and HER2 interactions in human breast cancer cell growth and survival
Cited by
- Protein tyrosine phosphatases in cancer: friends and foes!
- Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning
- Protein Tyrosine Phosphatases: Structure, Function, and Implication in Human Disease
- Role of the protein tyrosine phosphatase DEP-1 in Src activation and the mediation of biological cell functions of endothelial and breast cancer cells
- El silenciamiento de PTP1B disminuye la proliferación celular en cultivos primarios de cáncer de mama
- Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src
- PTP1B restrains mammary progenitor cells fate commitment and secretory differentiation
- The role of PTPRK and PTPRM in prostate and breast cancer
- The expression and functional role of protein tyrosine phosphatase 1B in breast epithelial cells
- Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus
- PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
- Flotillins as regulators of ErbB2 levels in breast cancer
- ER-Bound Protein Tyrosine Phosphatase PTP1B Interacts with Src at the Plasma Membrane/Substrate Interface
- Checks and balances: interplay of RTKs and PTPs in cancer progression.
- Protein-tyrosine Phosphatase PTPN9 Negatively Regulates ErbB2 and Epidermal Growth Factor Receptor Signaling in Breast Cancer Cells*
- In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis.
- Protein tyrosine phosphatase PTP1B in cell adhesion and migration
- Src signaling in cancer invasion
- Protein tyrosine phosphatase-1B and T-cell protein tyrosine phosphatase regulate IGF-2-induced MCF-7 cell migration.
- Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.
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