Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance.
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Summary
A role for NF-κB signaling in DCs for immune homeostasis and tolerance that could have implications in autoimmune diseases and immunity is described.
- Type
- article
- Published
- 2015-04-21
- Cited by
- 148
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1975660715
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20049237
Keywords
Biology, Immune system, Immune tolerance, Dendritic cell, Cell biology
References
- A high throughput Chromatin ImmunoPrecipitation approach reveals principles of dynamic gene regulation in mammals
- NF-κB and innate immunity.
- Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice
- T cell receptor antagonist peptides induce positive selection.
- Induction of T‐cell‐mediated skin disease specific for antigen transgenically expressed in keratinocytes
- CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
- Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll‐like receptor signaling
- IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses
- Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation.
- Control of RelB during dendritic cell activation integrates canonical and non-canonical NF-κB pathways
- Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen‐specific CD4+CD25+Foxp3+ regulatory T cells
- Entry into afferent lymphatics and maturation in situ of migrating murine cutaneous dendritic cells.
- I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection
- Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells.
- Differential responses of immune cells to type I interferon contribute to host resistance to viral infection.
- Conventional Dendritic Cells at the Crossroads Between Immunity and Cholesterol Homeostasis in Atherosclerosis
- Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute TH1 immune responses
- Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements
- Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome.
- IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation.
Cited by
- CCR7 Chemokine Receptor‐Inducible lnc‐Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF‐1&agr;‐Mediated Glycolysis
- MyD88 Signaling Regulates Steady-State Migration of Intestinal CD103+ Dendritic Cells Independently of TNF-α and the Gut Microbiota
- Engineering Immunity: Modulating Dendritic Cell Subsets and Lymph Node Response to Direct Immune-polarization and Vaccine Efficacy
- Study of dendritic cell migration using micro-fabrication.
- Molecular Phenotyping Small (Asian) versus Large (Western) Plaque Psoriasis Shows Common Activation of IL-17 Pathway Genes, but Different Regulatory Gene Sets
- Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Aggravates the Progression of Crescentic GN.
- Induction of CD4+ Regulatory and Polarized Effector/helper T Cells by Dendritic Cells
- Duality at the gate: Skin dendritic cells as mediators of vaccine immunity and tolerance
- Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery.
- Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation
- Antigen-Presenting Cells in the Skin.
- The origin of DCs and capacity for immunologic tolerance in central and peripheral tissues
- Dendritic cell migration in health and disease
- LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4+ regulatory T cell subpopulations mediated by 3G11 and CD127
- Dendritic Cells in the Immune System—History, Lineages, Tissues, Tolerance, and Immunity
- Mucosal immune tolerance at the ocular surface in health and disease
- Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions
- Intestinal Mononuclear Phagocytes in Health and Disease
- Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation
- Toll like receptor-induced murine dendritic cell activation requires dendritic cell-intrinsic complement
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