Control of RelB during dendritic cell activation integrates canonical and non-canonical NF-κB pathways
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Summary
It is reported that RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB pathway, but as a Rel B-p50 dimer regulated by canonical IκBs, IκBα andIκBɛ.
- Type
- article
- Published
- 2012-10-21
- Cited by
- 192
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1984387148
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8392037
Keywords
RELB, Cell biology, NF-κB, Signal transduction, Jurkat cells
References
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- Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3+ regulatory T-cell profile
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- Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers
- NF‐κB p52:RelB heterodimer recognizes two classes of κB sites with two distinct modes
Cited by
- Deleted in Breast Cancer 1 (DBC1) suppresses B cell activation through RelB and is regulated by IKKα phosphorylation
- Macrophages: Biology and Role in the Pathology of Diseases
- REGULATION OF YKL-40 IN STERILE INFLAMMATION AND ITS ROLE IN GLIOBLASTOMA IN VIVO
- The regulation of dendritic cell maturation and survival by tumour necrosis factor receptors 1 and 2
- Defining Mononuclear Phagocyte Subset Homology Across Several Distant Warm-Blooded Vertebrates Through Comparative Transcriptomics
- The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity
- NF‐κB2/p100 deficiency impairs immune responses to T‐cell‐independent type 2 antigens
- An agent-based model of the IL-1 stimulated Nuclear Factor-kappa B signalling pathway
- A less-canonical, canonical NF-κB pathway in DCs
- Molecular programming of steady‐state dendritic cells: impact on autoimmunity and tumor immune surveillance
- Dendritic cell maturation and survival are differentially regulated by TNF receptors 1 and 2
- Visualization of RelB expression and activation at the single-cell level during dendritic cell maturation in Relb-Venus knock-in mice.
- RelB/p50 complexes regulate cytokine-induced YKL-40 expression
- Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation
- p100, a precursor of NF-κB2, inhibits c-Rel and reduces the expression of IL-23 in dendritic cells.
- Role and therapeutic value of dendritic cells in central nervous system autoimmunity
- Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance.
- Computational Models of the NF-KB Signalling Pathway
- Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence
- Regulation of NF-κB by TNF Family Cytokines
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