Defective angiogenesis in mice lacking endoglin.
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Summary
It is shown that by gestational day 11.5, mice lacking endoglin die from defective vascular development, however, in contrast to mice lacking TGF-beta, vasculogenesis was unaffected and suggest a pathogenic mechanism for HHT1.
- Type
- article
- Published
- 1999-05-28
- Cited by
- 889
- References
- 16
- OpenAlex
- https://openalex.org/W1975522586
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45791860
Keywords
Endoglin, Angiogenesis, Vasculogenesis, Transforming growth factor, Transforming growth factor beta
References
- Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.
- Elastin is an essential determinant of arterial morphogenesis
- Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.
- Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.
- TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis.
- Blood vessel formation: what is its molecular basis?
- Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
- Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
- A new 180-kDa dermal endothelial cell activation antigen: in vitro and in situ characteristics.
- The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.
- Induction of vasculogenesis and hematopoiesis in vitro.
- Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
- PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle Fate
- SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis.
- Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.
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- Placental abruption : Studies on incidence, risk factors and potential predictive biomarkers
- Bioimmunotherapeutic targets on angiogenetic blood vessels in solid malignangies.
- NME1 suppression of endometrial stromal cells promotes angiogenesis in the endometriotic milieu via stimulating the secretion of IL-8 and VEGF.
- Getting Tie(2)d up in angiogenesis.
- Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain.
- Engineering vascularised tissues in vitro.
- Low-Level Expression of Smad7 Correlates with Lymph Node Metastasis and Poor Prognosis in Patients with Pancreatic Cancer
- Angiogenesis index CD105 (endoglin)/CD31 (PECAM-1) as a predictive factor for invasion and proliferation in intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
- Endothelial cells of oral pyogenic granulomas express eNOS and CD105/endoglin: an immunohistochemical study.
- Alteration in Endoglin-Related Angiogenesis in Refractory Cytopenia with Multilineage Dysplasia
- Rôle de la protéine Sonic Hedgehog dans la migration des cellules musculaires lisses et le recrutement des cellules murales sur les néovaisseaux : implication dans l’action de PDGF BB
- Flk-1 signalling during ES cell differentiation
- Angiogenesis in human renal cell carcinoma : hypoxia, vascularity and prognosis
- Ischemia Regulates Endoglin Expression in a Pig Skin Flap Model
- Expression and function of APRIL and GDF-5 in the developing hippocampus
- Angiogenesis and angioregression gene expression analyses in swine corpus luteum
- Vascular development: genetic mechanisms and links to vascular disease.
- 膵臓癌におけるEndoglin（CD105）の腫瘍内血管およびリンパ管内皮細胞での特異的な発現
- Transgenic mouse models of angiogenesis and lymphangiogenesis.
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