The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.
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Summary
Four areas have seen major progress in the TGF-p superfamily in the last 3 years: structural characterization of the signal ing molecule, isolation of new family members, cloning of receptor molecules, and new genetic tests of the func tions of these factors in different organisms.
- Type
- review
- Published
- 1994-01-01
- Cited by
- 2,041
- References
- 110
- Access
- Open access
- OpenAlex
- https://openalex.org/W2131211068
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36906631
Keywords
Biology, SUPERFAMILY, Function (biology), Genetics, Receptor
References
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- Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.
- A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.
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- The decapentaplegic gene: a TGF-beta homologue controlling pattern formation in Drosophila.
- Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
- Mechanism of the pleiotropic effects of the short-ear mutant gene in the mouse.
- Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
- Identification of two regions from the Drosophila decapentaplegic gene required for embryonic midgut development and larval viability.
- The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily.
- Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.
Cited by
- Activin: a novel player in tissue repair processes.
- Bone morphogenetic proteins inhibit proliferation, induce reversible differentiation and prevent cell death in astrocyte lineage cells.
- Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members
- Neurturin, a relative of glial-cell-line-derived neurotrophic factor
- Changes of dimeric inhibin B levels in maternal serum throughout healthy gestation and in women with gestational diseases.
- Pioneer axon guidance by UNC-129, a C. elegans TGF-beta.
- TGF-β3, but Not TGF-β1, Protects Keratinocytes against 12-O-Tetradecanoylphorbol-13-acetate-induced Cell Deathin Vitro and in Vivo *
- Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker.
- Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation.
- TGF-β1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis.
- Sea urchin TgBMP2/4 gene encoding a bone morphogenetic protein closely related to vertebrate BMP2 and BMP4 with maximal expression at the later stages of embryonic development.
- The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis.
- Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8‐mediated signalling
- Bone morphogenetic proteins in human bone regeneration.
- Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissues.
- Effect of Beta–Sitosterol on Transforming Growth Factor–Beta–1 Expression and Translocation Protein Kinase C Alpha in Human Prostate Stromal Cells in vitro
- Influence of Non-Neuronal Cells on Establishment of Neuropeptide Y Expression by Sympathetic Neurons in vitro
- Crouzon's syndrome: differential in vitro secretion of bFGF, TGFbeta I isoforms and extracellular matrix macromolecules in patients with FGFR2 gene mutation.
- Molecular characterisation of sea bream (Sparus aurata) transforming growth factor beta1.
- Glycosylphosphatidylinositol-anchored Proteins Regulate Transforming Growth Factor-β Signaling in Human Keratinocytes*
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