Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects

Keywords

Polyketide, Metabolic engineering, Biology, Gene, Biosynthesis

References

• Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK.Kubendran Naidoo — 1995
• Modification of post-PKS tailoring steps through combinatorial biosynthesis.Edward Humphreys — 2002
• Review of macrolides and ketolides: focus on respiratory tract infections.George G. Zhanel, Maria Dueck, Daryl J. Hoban — 2001
• Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.Charles E. Melançon, Haruko Takahashi, Hung‐wen Liu — 2004
• The polyketide metabolitesD. O'Hagan — 1991
• Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilisHaruo Ikeda, Jun Ishikawa, Akiharu Hanamoto — 2003
• New erythromycin derivatives from Saccharopolyspora erythraea using sugar O‐methyltransferases from the spinosyn biosynthetic gene clusterSabine Gaisser, Rachel E. Lill, Gabriele Wirtz — 2001
• Identification of an isozymic form of acetyl-CoA carboxylase.Anderson Elias Bianchi, Joseph L. Evans, A J Iverson — 1990
• Parallel pathways for oxidation of 14‐membered polyketide macrolactones in Saccharopolyspora erythraeaSabine Gaisser, Rachel E. Lill, James Staunton — 2002
• Biosynthesis and attachment of novel bacterial polyketide synthase starter units.Bradley S. Moore, Christian Hertweck — 2002
• Engineered biosynthesis of a complete macrolactone in a heterologous host.Camilla M. Kao, Leonard Katz, Chaitan Khosla — 1994
• The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae*David H. Sherman, Shengying Li, Liudmila V. Yermalitskaya — 2006
• A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.Ralph Reid, Misty Piagentini, Eduardo Rodrı́guez — 2003
• TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene.Charles E. Melançon, Wei-luen Yu, Hung‐wen Liu — 2005
• Low pH-induced membrane fatty acid alterations in oral bacteria.Elizabeth M. Fozo, Jessica K. Kajfasz, R QUIVEYJR — 2004
• Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae.Yeo Joon Yoon, Brian J. Beck, Beom Seok Kim — 2002
• Engineered synthesis of 7-oxo- and 15-deoxy-15-oxo-amphotericins: insights into structure-activity relationships in polyene antibiotics.Patrick Power, Terence Dunne, Barry Murphy — 2008
• Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production.Andrew R. Reeves, Igor Brikun, William H. Cernota — 2007
• Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursorSangJoon Mo, Yeon-Hee Ban, Je Won Park — 2009
• Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.Christopher D. Reeves, Sumati Murli, Gary W. Ashley — 2001

Cited by

• Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar‐containing antibioticsMootz, James M. M. Francis — 2017
• Essential role of genetics in the advancement of biotechnology.Arnold L. Demain, José L. Adrio — 2012
• THE DISCOVERY AND STUDY OF FLUVIRUCIN B1 POLYKETIDE SYNTHASETsung-Yi Lin — 2014
• Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discoveryEun Ji Kim, Inho Yang, Yeo Joon Yoon — 2015
• Knocking out of tailoring genes eryK and eryG in an industrial erythromycin‐producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C and D at different conversion ratiosQ. Zhang, Jizhong Wu, Jiangchao Qian — 2011
• Chemoenzymatic Synthesis of Glycosylated Macrolactam Analogues of the Macrolide Antibiotic YC‐17Pramod B. Shinde, Hong‐Se Oh, Hyemin Choi — 2015
• Bacterial l-leucine catabolism as a source of secondary metabolitesAlma Laura Díaz-Pérez, César Díaz‐Pérez, Jesús Campos‐García — 2016
• Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-MethyltransferasesSteffen M. Bernard, David L. Akey, Ashootosh Tripathi — 2015
• Production of a hybrid 16-membered macrolide antibiotic by genetic engineering of Micromonospora sp. TPMA0041Ayami Sakai, Aki Mitsumori, Mika Furukawa — 2012
• Microbial natural products: molecular blueprints for antitumor drugsLesleyAnn Giddings, David Newman — 2013
• Streptomyces nodosus Host Strains Optimized for Polyene Glycosylation EngineeringNiamh Stephens, Bernard J. Rawlings, Patrick Caffrey — 2012
• 2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways.Sung Ryeol Park, Je Won Park, Yeon Hee Ban — 2013
• Heterologous Production of 4-O-Demethylbarbamide, a Marine Cyanobacterial Natural ProductEun Ji Kim, Jong Hyun Lee, Hyukjae Choi — 2012
• A Comprehensive Review of Aliphatic Hydrocarbon Biodegradation by BacteriaFirouz Abbasian, Robin Lockington, Mallavarapu Megharaj — 2015
• A new mycinosyl rosamicin derivative produced by an engineered Micromonospora rosaria mutant with a cytochrome P450 gene disruption introducing the d-mycinose biosynthetic geneYohei Iizaka, Noriko Higashi, Wei Li — 2014
• Characterization and engineering of the ethylmalonyl-CoA pathway towards the improved heterologous production of polyketides in Streptomyces venezuelaeWon Seok Jung, Eunji Kim, Young Ji Yoo — 2014
• Blastocystis Is Associated with Decrease of Fecal Microbiota Protective Bacteria: Comparative Analysis between Patients with Irritable Bowel Syndrome and Control SubjectsCéline Nourrisson, Julien Scanzi, Bruno Pereira — 2014
• Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activitiesAh Reum Han, Pramod B. Shinde, Je Won Park — 2011
• Importance of microbial natural products and the need to revitalize their discoveryArnold L. Demain — 2014
• A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253Won Seok Jung, Young Ji Yoo, Je Won Park — 2011

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