Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts.

Keywords

Polyketide, Polyketide synthase, Heterologous expression, Heterologous, Escherichia coli

References

• Polyketide synthase acyl carrier proteins from Streptomyces: expression in Escherichia coli, purification and partial characterisation.Hitoshi Matsushima — 1995
• Regulation of pantothenate kinase by coenzyme A and its thioesters.David S. Vallari, Suzanne Jackowski, Charles O. Rock — 1987
• Regulation of coenzyme A biosynthesisSuzanne Jackowski, Charles O. Rock — 1981
• Handbook of microbiological mediaRonald M. Atlas, Ronald M. Atlas — 1993
• Engineered biosynthesis of a complete macrolactone in a heterologous host.Camilla M. Kao, Leonard Katz, Chaitan Khosla — 1994
• Expression of a functional non-ribosomal peptide synthetase module in Escherichia coli by coexpression with a phosphopantetheinyl transferase.Jung Ku, Raghavendra G. Mirmira, Lu Liu — 1997
• Characterization of tyrocidine synthetase 1 (TY1): requirement of posttranslational modification for peptide biosynthesis.Eva Pfeifer, Maja Pavela‐Vrančić, Hans von Doehren — 1995
• Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum.Jonathan B. Spencer, Peter M. Jordan — 1992
• A new enzyme superfamily - the phosphopantetheinyl transferases.Ralph H. Lambalot, Amy M. Gehring, Roger S. Flugel — 1996
• Combinatorial biosynthesis of 'unnatural' natural products: the polyketide example.Carrie Tsoi, Chaitan Khosla — 1995
• Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase.Gareth A. Roberts, James Staunton, Peter F. Leadlay — 1993
• Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics.C. Richard Hutchinson, Isao Fujii — 1995
• Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)David J. Bedford, Eckhart Schweizer, David A. Hopwood — 1995
• The combinatorial chemistry of nature.Gregory L. Verdine — 1996
• Handbook of microbiological media1994
• Current protocols in molecular biology1988

Cited by

• The biosynthesis of coenzyme A in bacteria.Sergio Romano — 2001
• Process development and metabolic engineering for the overproduction of natural and unnatural polyketides.Robert McDaniel, Peter Licari, Chaitan Khosla — 2001
• Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae.Flávia Moreira Lima — 2006
• Synthesis of C‐Glucosylated Octaketide Anthraquinones in Nicotiana benthamiana by Using a Multispecies‐Based Biosynthetic PathwayToya A. Wyatt — 2017
• Chapter 15. Plasmid-borne gene cluster assemblage and heterologous biosynthesis of nonribosomal peptides in Escherichia coli.Kenji Watanabe, Alex P. Praseuth, Mike B. Praseuth — 2009
• Genetic potential of lichen-forming fungi in polyketide biosynthesisYit‐Heng Chooi — 2008
• Studies on the biosynthesis of antibiotic nystatin with emphasis on regulationOlga N. Sekurova — 2013
• Manipulating posttranslational modification in natural product biosynthesisTimothy L. Foley — 2010
• Improving heterologous polyketide production in Escherichia coli by transporter engineeringJingya Yang, Zhiqiang Xiong, Shujie Song — 2015
• Multiplexed Mass Spectrometric Approaches for Protein Cross-Linking Analysis and Protein Functional Studies.Bo Wang — 2010
• Investigating intermediates in 6-methylsalicylic acid biosynthesisHelen K. Potter — 2011
• Synthetic biology of fungal natural productsDerek J. Mattern, Vito Valiante, Shiela E. Unkles — 2015
• Fungal type I polyketide synthases.Russell J. Cox, Thomas J. Simpson — 2009
• Synthesis of galactose-containing oligosaccharides through superbeads and superbug approaches: substrate recognition along different biosynthetic pathways.Jianbo Zhang, Xi Chen, Jun Shao — 2003
• Chapter 10 using phosphopantetheinyl transferases for enzyme posttranslational activation, site specific protein labeling and identification of natural product biosynthetic gene clusters from bacterial genomes.Murat Sünbül, Keya Zhang, Jun Yin — 2009
• Systems biology of industrial microorganisms.Marta Papini, Margarita Salazar, Jens Nielsen — 2010
• Harnessing Saccharomyces cerevisiae Genetics for Cell EngineeringLaura M. Wingler — 2011
• Modulation of genetic clusters for synthesis of bioactive molecules in fungal endophytes: A review.Vishwanath Bhat Deepika, T. S. Murali, Kapaettu Satyamoorthy — 2016
• Yeast as a cell factory: current state and perspectivesMartin Kavšček, Martin Stražar, Tomaž Curk — 2015
• Engineering of modular polyketide synthases to produce novel polyketides.Christopher W. Carreras, Daniel V. Santi — 1998

Related papers

• Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase–Polyketide Synthase Interface for Leinamycin BiosynthesisYong Huang, Gong-Li Tang, Guohui Pan — 2016
• Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coliWenjun Zhang, Yanran Li, Yi Tang — 2008
• Construction and performance of heterologous polyketide‐producing K‐12‐ and B‐derived Escherichia coliJinghui Wu, Brett A. Boghigian, Melissa Myint — 2010
• Precursor-Directed polyketide biosynthesis in Escherichia coli.Kenji Kinoshita, Blaine A. Pfeifer, Chaitan Khosla — 2003
• Elucidation and Heterologous Reconstitution of Chrodrimanin B Biosynthesis.Tongxuan Bai, Zhiyang Quan, Rui Zhai — 2018
• Biosynthesis of Cell Envelope-Associated Phenolic Glycolipids in Mycobacterium marinumOlivia Vergnolle, Sivagami Sundaram Chavadi, Uthamaphani R. Edupuganti — 2015
• Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis.Takahiro Ugai, Atsushi Minami, Ryuya Fujii — 2015
• Heterologous expression, purification, and characterization of type II polyketide acyl carrier proteinsGrayson S. Hamrick, Casey H. Londergan, Louise K. Charkoudian — 2022
• Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase.Li Tang, Hong Fu, Melanie C Betlach — 1999