Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.
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Summary
Findings indicate that the decrease in kinase activity in NIDDM resulted from a reduction in coupling efficiency between insulin binding and activation of the receptor kinase, which could be etiologically related to insulin resistance in NIDs and the pathogenesis of the diabetic state.
- Type
- article
- Published
- 1987-01-01
- Cited by
- 244
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2169226001
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38004867
Keywords
Autophosphorylation, Insulin receptor, Internal medicine, Endocrinology, Insulin
References
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- Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro.
- The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.
- Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance.
- Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells.
- Insulin stimulated phosphorylation of its own receptor. Activation of a tyrosine-specific protein kinase that is tightly associated with the receptor.
- beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.
- The structure of insulin receptor and its subunits. Evidence for multiple nonreduced forms and a 210,000 possible proreceptor.
- Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.
- Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo.
- Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system.
- Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues.
- Receptor aggregation is necessary for activation of the soluble insulin receptor kinase.
- Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin.
- The Metabolism of Isolated Fat Cells: I. Effects of Hormones on Glucose Metabolism and Lipolysis
Cited by
- Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome
- Association of genetic variant of the glucose transporter with non-insulin-dependent diabetes mellitus.
- Diverse signaling pathways in the cellular actions of insulin.
- Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling.
- Troglitazone ameliorates abnormal activity of protein tyrosine phosphatase in adipose tissues of Otsuka Long-Evans Tokushima Fatty rats.
- Toward a Mechanistic Understanding of Hepatic Insulin Action and Resistance
- Insulin signaling dynamics in human adipocytes : Mathematical modeling reveals mechanisms of insulin resistance in type 2 diabetes
- Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats
- Clinical Research in Diabetes and Obesity
- Diabetes Mellitus: Pathophysiology and Therapy
- Prospektive, randomisierte, kontrollierte Studie zur Prävention des Typ 2Diabetes mellitus bei adipösen Kindern und Jugendlichen
- Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction
- The paradoxical regulation of protein phosphorylation in insulin action
- Nutritional and endocine modulation of intracellular calcium: Implications in obesity, insulin resistance and hypertension
- Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate breakdown in liver from humans with and without type II diabetes.
- Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice
- Phosphorylation of the insulin receptor kinase by phosphocreatine in combination with hydrogen peroxide: the structural basis of redox priming
- Changes in insulin receptor kinase with aging in rat skeletal muscle and liver.
- Insulin receptor kinase defects in insulin-resistant tissues and their role in the pathogenesis of NIDDM.
- Fibroblasts from a leprechaun patient have defects in insulin binding and insulin receptor autophosphorvlation
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