Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26
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Summary
The structure of the HKU4-RBD/hCD26 complex revealed a hCD26-binding mode similar overall to that observed for MERS-RBD, however, HKU4-RBD is less adapted to hCD26 than MERS-RBD, explaining its lower affinity for receptor binding.
- Type
- article
- Published
- 2014-09-10
- Cited by
- 310
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973757205
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25154538
Keywords
Biology, Coronavirus disease 2019 (COVID-19), Coronavirus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Virology
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- Structural Basis for Coronavirus-mediated Membrane Fusion
Cited by
- The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses
- Bats as reservoirs of severe emerging infectious diseases
- Targeting zoonotic viruses: structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 – the likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)
- Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27
- Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond
- Re-emerging Middle East respiratory syndrome coronavirus: The hibernating bat hypothesis
- Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus
- Crystal Structure of Herpes Simplex Virus 2 gD Bound to Nectin-1 Reveals a Conserved Mode of Receptor Recognition
- Host cell proteases: critical determinants of coronavirus tropism and pathogenesis
- A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus
- CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection
- A structural view of coronavirus–receptor interactions
- Detection of coronavirus genomes in Moluccan naked-backed fruit bats in Indonesia
- Middle East Respiratory Syndrome Coronavirus “MERS-CoV”: Current Knowledge Gaps
- Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease
- Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural Studies
- Middle East Respiratory Syndrome
- Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives.
- Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.
- Evidence for zoonotic origins of Middle East respiratory syndrome coronavirus
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