CD26: A Multifunctional Integral Membrane and Secreted Protein of Activated Lymphocytes
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Summary
The focus of this review is the structure and function of CD 26 and the influence of its ligand binding activity on T‐cell proliferation and the T cell costimulatory activity of CD26.
- Type
- review
- Published
- 2001-09-01
- Cited by
- 394
- References
- 219
- Access
- Open access
- OpenAlex
- https://openalex.org/W2030005765
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43311237
Keywords
T cell, Dipeptidyl peptidase, Cell biology, Aminopeptidase, T-cell receptor
References
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- Proteins of the kidney microvillar membrane. The amphipathic form of dipeptidyl peptidase IV.
- Tissue distribution of the T cell activation antigen Ta1. Serological, immunohistochemical and biochemical investigations.
- CD26 induces T-cell proliferation by tyrosine protein phosphorylation.
- The Physical Map
- Post-proline-cleaving peptidases having DP IV like enzyme activity. Post-proline peptidases.
- Relating structure to function in the beta-propeller domain of dipeptidyl peptidase IV. Point mutations that influence adenosine deaminase binding, antibody binding and enzyme activity.
- Role of adenosine deaminase in lymphocyte proliferation.
- Biosynthesis of intestinal microvillar proteins. Role of the Golgi complex and microtubules.
- Elevated adenosine deaminase and purine nucleoside phosphorylase activity in peripheral blood null lymphocytes from patients with acquired immune deficiency syndrome.
- Molecular analyses of human and rat dipeptidyl peptidase IV.
- Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule.
- Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness.
- Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response.
- Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways.
- Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist.
- 1F7, a novel cell surface molecule, involved in helper function of CD4 cells.
- CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3.
- Natural substrates of dipeptidyl peptidase IV.
Cited by
- A study of a proline specific seprase activity from mammalian serum
- CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse.
- Distribution of Dipeptidyl Peptidase IV in Patients with Chronic Tonsillitis
- Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition.
- Proteomic analysis of two types of exosomes in human whole saliva.
- Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis.
- CD26: a key molecule in immune regulation and autoimmune diseases
- Regulation of Pulmonary Graft-versus-Host Disease by IL-26+CD26+CD4 T Lymphocytes
- CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome
- Cell-Surface Peptidases
- The study of a new and specific proline cleaving peptidase from bovine serum
- Up-regulated dipeptidyl-peptidase IV (CD26) on monocytes was unaffected by effective DMARD treatment in early steroid and DMARD-naive rheumatoid arthritis.
- Ectopeptidases in tumour biology: a review.
- Fibroblast activation protein-α: a key modulator of the microenvironment in multiple pathologies.
- Mapeamento do padrão de expressão tecidual dos genes relacionados à adenosina deaminase e caracterização cinética da atividade de desaminação da adenosina em cérebro de zebrafish (Danio rerio)
- Molecular chimeras and mutational analysis in the prolyl oligopeptidase gene family.
- The role of gliptins on adipogenesis
- Adenosine stimulation of the proliferation of colorectal carcinoma cell lines. Roles of cell density and adenosine metabolism.
- Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection.
- Analysis of Microtubule Mediated Functions of Prostate Specific Membrane Antigen
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