miR-100-5p inhibition induces apoptosis in dormant prostate cancer cells and prevents the emergence of castration-resistant prostate cancer
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Summary
The results suggest that mir-100-5p is a possible therapeutic target involved in prostate cancer progression and relapse post androgen ablation therapy, and is associated with clinical outcome.
- Type
- article
- Published
- 2017-06-22
- Cited by
- 44
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2625285070
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23340023
Keywords
Prostate cancer, Medicine, Prostate, Cancer, Cancer research
References
- Traditional androgen ablation approaches to advanced prostate cancer: new insights.
- In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis.
- Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer
- C/EBPα-induced miR-100 expression suppresses tumor metastasis and growth by targeting ZBTB7A in gastric cancer.
- Transdifferentiation of cultured human prostate cancer cells to a neuroendocrine cell phenotype in a hormone-depleted medium.
- Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells
- The epigenetic/noncoding origin of tumor dormancy.
- Models, mechanisms and clinical evidence for cancer dormancy
- MicroRNA-100 expression is independently related to biochemical recurrence of prostate cancer.
- Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis.
- Regulation of microRNA biogenesis
- Metastasis: Dissemination and growth of cancer cells in metastatic sites
- Most mammalian mRNAs are conserved targets of microRNAs.
- Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora‐B
- miR-100 Induces Epithelial-Mesenchymal Transition but Suppresses Tumorigenesis, Migration and Invasion
- MicroRNA—implications for cancer
- MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use
- Dissecting the metastatic cascade
- Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer
- The non-coding transcriptome as a dynamic regulator of cancer metastasis
Cited by
- Unveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires
- Cell Cycle Regulation of Stem Cells by MicroRNAs
- Neuroendocrine differentiation of prostate cancer leads to PSMA suppression.
- Exosome: a novel mediator in drug resistance of cancer cells.
- Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer
- Treatment-emergent neuroendocrine prostate cancer: molecularly driven clinical guidelines
- Plasma miR-200c-3p, miR-100-5p, and miR-1826 serve as potential diagnostic biomarkers for knee osteoarthritis
- Oncogenic and tumor-suppressive microRNAs in prostate cancer
- The mechanistic role of long non-coding RNAs in advanced prostate cancer response to therapy
- MiR-29 regulates the function of goat granulosa cell by targeting PTX3 via the PI3K/AKT/mTOR and Erk1/2 signaling pathways.
- miR-100-5p downregulates mTOR to suppress the proliferation, migration and invasion of prostate cancer cells
- PDX: Moving Beyond Drug Screening to Versatile Models for Research Discovery
- miR-100-5p Downregulates mTOR to Suppress the Proliferation, Migration, and Invasion of Prostate Cancer Cells
- MicroRNA‐99 family in cancer and immunity
- Integrated Analysis of Circular RNA Associated Cerna Network Reveals Potential CircRNA Biomarkers in Human Breast Cancer
- microRNAs Mediated Regulation of the Ribosomal Proteins and its Consequences on the Global Translation of Proteins
- Diterpenoid anthraquinones as chemopreventive agents altered microRNA and transcriptome expressions in cancer cells.
- Identifying Potential Off-Target Protein Binders of Glutamate-Ureido-Lysine, a Prostate Cancer Specific Imaging Agent
- The role of single nucleotide polymorphisms of miRNAs 100 and 146a as prognostic factors for prostate cancer
- Role of noncoding RNA in drug resistance of prostate cancer
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