A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.
Explore this paper's citation graph
Summary
It is found that 14/24 (58%) of invasive squamous cell carcinomas of the skin contain mutations in the p53 tumor suppressor gene, each altering the amino acid sequence, which is believed to identify a carcinogen-related step in a gene involved in the subsequent human cancer.
- Type
- dissertation
- Published
- 1991-11-15
- Cited by
- 1,980
- References
- 0
- OpenAlex
- https://openalex.org/W1946433
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42765532
Keywords
Biology, Humanities, Art
References
No references recorded for this paper.
Cited by
- Mad dogs, Englishmen and apoptosis: The role of cell death in UV-induced skin cancer
- Effects of ultraviolet radiation on skin cell proteome.
- Molecular changes in human melanoma metastasis.
- Demonstration of DNA damage/repair in individual cells using in situ end labelling: Association of p53 with sites of DNA damage
- Characterization of ultraviolet radiation-induced damage to keratinocytes in a skin equivalent in vitro
- Analysis of p53 gene mutations and loss of heterozygosity for loci on chromosome 9q in basal cell carcinoma.
- Loss of heterozygosity analysis of keratoacanthoma reveals multiple differences from cutaneous squamous cell carcinoma.
- p53 gene mutations in skin cancers with underlying disorders.
- Quantitative Determination of Cyclobutane Thymine Dimers in DNA by Stable Isotope‐Dilution Mass Spectrometry
- Identification of the genes encoding cancer antigens: implications for cancer immunotherapy.
- Mutagenic Lesions in Photocarcinogenesis: The Fate of Pyrimidine Photoproducts in Repair‐Deficient Disorders
- Inhibition of cyclobutane pyrimidine dimer formation in epidermal p53 gene of UV-irradiated mice by alpha-tocopherol.
- p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis
- Head and Neck Cancer in Cardiothoracic Transplant Recipients
- Acute dorsal skin responses to UVB-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats.
- Ultraviolet B-induced melanoma in Monodelphis domestica occurs in the absence of alterations in the structure or expression of the p53 gene
- UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53
- Rôle des mélanocytes dans l'unité épidermique de mélanisation reconstruite ex-vivo après une irradiation UV aiguë
- Overexpression of wild-type p53 in lichen sclerosus adjacent to human papillomavirus-negative vulvar cancer.
- Volume, trend and citation analyses of skin related publications from 1966 to 2003.
Related papers
No related papers recorded.