Recent progress on bioinformatics, functional genomics, and metabolomics research of cytochrome P450 and its impact on drug discovery.
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Summary
The recent progress on cytochrome P450 and its role on drug metabolism in the context of bioinformatics, functional genomics and metabolomics is summarized.
- Type
- review
- Published
- 2012-05-31
- Cited by
- 10
- References
- 120
- OpenAlex
- https://openalex.org/W1973648662
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24359752
Keywords
Metabolomics, Drug discovery, Context (archaeology), Functional genomics, Genomics
References
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- Metabonomics in pharmaceutical discovery and development.
- Binding of CYP2C9 with diverse drugs and its implications for metabolic mechanism.
- Functional informatics: convergence and integration of automation and bioinformatics.
- Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism
- Virtual Screening for SARS-CoV Protease Based on KZ7088 Pharmacophore Points
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Cited by
- The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis.
- Modeling Complex Metabolic Reactions, Ecological Systems, and Financial and Legal Networks with MIANN Models Based on Markov-Wiener Node Descriptors
- Molecular Cloning and Characterization of a Novel P450 Gene Encoding CYP6BK18 From Dastarcus helophoroides (Coleoptera: Bothrideridae)
- Pharmacological or genetic inhibition of Scn9a protects beta-cells while reducing insulin secretion in type 1 diabetes
- A literature review on Toxicogenomics
- Toxicity Derived from Interaction between Natural Compounds and Cancer Therapeutic Drugs Metabolized by CYP3A4: Lessons Learned from Two Clinical Case Reports
- Designing cytochrome P450 enzymes for use in cancer gene therapy
- Molecular Characterization in 3D Structure of MicroRNA Expressed in Leprosy
- 3D-Structural Characterization of MicroRNA Expressed in Leprosy
- Consideration of Metabolism in In Vitro Cellular Systems
- Toxicogenomics – A Drug Development Perspective
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