Metabonomics: a platform for studying drug toxicity and gene function
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Summary
Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process.
- Type
- review
- Published
- 2002-01-30
- Cited by
- 1,841
- References
- 86
- OpenAlex
- https://openalex.org/W1797956629
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17881327
Keywords
Drug discovery, Drug development, Function (biology), Drug, Pipeline (software)
References
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- Application of pattern recognition methods to the analysis and classification of toxicological data derived from proton nuclear magnetic resonance spectroscopy of urine.
- A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
- Characterization of diet-dependent metabolic serotypes: analytical and biological variability issues in rats.
- Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids
- Measurement of biomolecular diffusion coefficients in blood plasma using two-dimensional 1H-1H diffusion-edited total-correlation NMR spectroscopy.
- 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
- Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes
- Pattern recognition methods and applications in biomedical magnetic resonance
- Chemometrics: A Practical Guide
- Metabolic profiling of chronic cadmium exposure in the rat.
- Key challenges for toxicologists in the 21st century.
- Impact of ethanol stress on components of the allantoic fluid of the chicken embryo.
- NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach.
- Pattern recognition analysis of high resolution 1H NMR spectra of urine. A nonlinear mapping approach to the classification of toxicological data
- Pattern recognition used to investigate multivariate data in analytical chemistry.
- Proton MRS of human prostatic fluid: Correlations between citrate, spermine, and myo‐inositol levels and changes with disease
Cited by
- Platforms for biomarker analysis using high-throughput approaches in genomics, transcriptomics, proteomics, metabolomics, and bioinformatics.
- Toxic plants: a chemist's perspective.
- The clinical chemome: a tool for the diagnosis and management of chronic disease.
- LC-MS-based metabonomics analysis.
- Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
- Analysis of highly polar metabolites in human plasma by ultra-performance hydrophilic interaction liquid chromatography coupled with quadrupole-time of flight mass spectrometry.
- Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine.
- Early detection of immunization: a study based on an animal model using 1H nuclear magnetic resonance spectroscopy.
- Target discovery and validation.
- Metabolomics in chronic kidney disease.
- Current practice of liquid chromatography-mass spectrometry in metabolomics and metabonomics.
- Review article: small intestinal bacterial overgrowth – prevalence, clinical features, current and developing diagnostic tests, and treatment
- 1H NMR based metabolic profiling in Crohn's disease by random forest methodology
- Metabolomics and the great obstetrical syndromes--GDM, PET, and IUGR.
- 1H-NMR メタボローム解析を用いた絶食下コイ Cyprinus carpio L. の血漿中代謝物変動評価
- Metabolic Perturbation and Potential Markers in Patients with Esophageal Cancer
- The role of mass spectrometry in studies of glycation processes and diabetes management.
- Multifaceted Nutritional Intervention In Hemodialysis Patients
- Biomarker discovery for drug development and translational medicine using metabonomics.
- Application de la RMN HRMAS en Cancérologie “Modèles métaboliques de classification des tumeurs cérébrales”
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