Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment.
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Summary
PD-1/PD-L1 blockade has an immunoregulatory activity which may synergize with the antiviral effect of IFN-alpha therapy and should be thus explored further in long-lasting chronic HCV infections in the perspective of improving the efficacy of available antiviral treatments.
- Type
- article
- Published
- 2008-04-01
- Cited by
- 136
- References
- 49
- OpenAlex
- https://openalex.org/W1973452228
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22442657
Keywords
Viremia, Immunology, Medicine, Interferon, Cytokine
References
- Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction
- Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection1
- B7-H1 Up-Regulation on Myeloid Dendritic Cells Significantly Suppresses T Cell Immune Function in Patients with Chronic Hepatitis B1
- B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
- PD-1:PD-L1 Interactions Contribute to the Functional Suppression of Virus-Specific CD8+ T Lymphocytes in the Liver1
- PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
- Adaptive immune responses in acute and chronic hepatitis C virus infection
- Kinetics of the immune response during HBV and HCV infection
- PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion
- B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.
- T and B cells in hepatitis C virus control: what they do and when they fail.
- Evasion of intracellular host defence by hepatitis C virus
- Dysfunction and functional restoration of HCV‐specific CD8 responses in chronic hepatitis C virus infection
- Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
- Molecular signature of CD8+ T cell exhaustion during chronic viral infection.
- Oscillating CD8(+) T cell effector functions after antigen recognition in the liver.
- Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus
- B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin 10 secretion
- The roles of the new negative T cell costimulatory pathways in regulating autoimmunity.
- Outcome of acute hepatitis C is related to virus‐specific CD4 function and maturation of antiviral memory CD8 responses
Cited by
- Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C.
- Immunotherapy of viral infections.
- Biomarqueurs des états septiques sévères : vers de nouvelles stratégies thérapeutiques individualisées
- Alcohol and HCV: implications for liver cancer.
- Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma.
- Biological Basis of Alcohol-Induced Cancer
- Improvement of therapeutic vaccination for the treatment of chronic hepatitis B in a preclinical model (woodchuck)
- The Impact of Negative Regulation on T cell Immunity During Chronic Hepatitis C Virus Infections: A study on immunity of liver and peripheral blood
- Minimal Dose Interferon Suppository Treatment Suppresses Viral Replication with Platelet Counts and Serum Albumin Levels Increased in Chronically Hepatitis C Virus-Infected Patients: A Phase 1b, Placebo-Controlled, Randomized Study
- Heterologous T Cells Can Help Restore Function in Dysfunctional Hepatitis C Virus Nonstructural 3/4A-Specific T Cells during Therapeutic Vaccination
- Adaptive Immunity to the Hepatitis C Virus
- Lymphocytes and liver fibrosis in HIV & HCV coinfection
- Dendritic Cell Inhibition Is Connected to Exhaustion of CD8+ T Cell Polyfunctionality during Chronic Hepatitis C Virus Infection
- Type I Interferon Modulates the Battle of Host Immune System Against Viruses
- Managing hepatitis C in liver transplant patients with recurrent infection
- The role of the PD‐1 pathway in autoimmunity and peripheral tolerance
- Characterization of the HCMV-Specific CD4 T Cell Responses that Are Associated with Protective Immunity
- Inhibitory receptor molecules in chronic hepatitis B and C infections: novel targets for immunotherapy?
- PD‐1/PD‐L1 pathway and T‐cell exhaustion in chronic hepatitis virus infection
- Coinfection With HIV-1 and HCV—A One-Two Punch
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