PD‐1/PD‐L1 pathway and T‐cell exhaustion in chronic hepatitis virus infection
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Summary
The latest research on PD‐1/PD‐L1 pathway and T‐cell exhaustion in the context of human chronic hepatitis B and C virus infections and the therapeutic potential ofPD‐1 blockade and how it may be enhanced through the modulation of other co‐stimulatory/inhibitory pathways are reviewed.
- Type
- review
- Published
- 2010-07-01
- Cited by
- 106
- References
- 63
- OpenAlex
- https://openalex.org/W1961215690
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46195566
Keywords
Blockade, Chronic hepatitis, Context (archaeology), Virus, Dysfunctional family
References
- Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction
- PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV.
- 4-1BBL Induces TNF Receptor-Associated Factor 1-Dependent Bim Modulation in Human T Cells and Is a Critical Component in the Costimulation-Dependent Rescue of Functionally Impaired HIV-Specific CD8 T Cells1
- Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment.
- Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses.
- PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
- Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B.
- Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C.
- Recurrence of hepatitis C virus after loss of virus specific CD4+ T cell response in acute hepatitis C
- Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection.
- Course and outcome of hepatitis C
- Chronically Inflamed Livers Up-regulate Expression of Inhibitory B7 Family Members
- Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
- Dysfunction and functional restoration of HCV‐specific CD8 responses in chronic hepatitis C virus infection
- Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
- Selection of high‐avidity CD8 T cells correlates with control of hepatitis C virus infection
- Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma.
- Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B.
- Analysis of a successful immune response against hepatitis C virus.
- Enhancing SIV-Specific Immunity In Vivo by PD-1 Blockade
Cited by
- Biomarqueurs des états septiques sévères : vers de nouvelles stratégies thérapeutiques individualisées
- Novel immunotherapeutic strategies after stem cell transplantation. Boosting graft-versus-tumor immunity by interference with co-inhibitory signaling
- An unbalanced PD-L1/CD86 ratio in CD14++CD16+ monocytes is correlated with HCV viremia during chronic HCV infection
- Differential presentation of endogenous and exogenous hepatitis B surface antigens influences priming of CD8+ T cells in an epitope‐specific manner
- Effect of the infectious dose and the presence of hepatitis C virus core gene on mouse intrahepatic CD8 T cells
- Serum interferon gamma level predicts recurrence in hepatocellular carcinoma patients after curative treatments
- Lymphocytes and liver fibrosis in HIV & HCV coinfection
- Tolerancia inmunitaria y mecanismos de evasión en la respuesta frente a virus: Amigos o enemigos
- The Expression of Programmed Death-1 in Circulating CD4+ and CD8+ T Cells during Hepatitis B Virus Infection Progression and Its Correlation with Clinical Baseline Characteristics
- Therapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: perspectives and challenges.
- Increased expression of programmed death (PD)‐1 and its ligand PD‐L1 correlates with impaired cell‐mediated immunity in high‐risk human papillomavirus‐related cervical intraepithelial neoplasia
- Downregulation of Immunosuppressive Environment in Patients with Chronic HBV Hepatitis on Maintained Remission
- The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses
- Complementary Role of HCV and HIV in T-Cell Activation and Exhaustion in HIV/HCV Coinfection
- B and T lymphocyte attenuator is highly expressed on intrahepatic T cells during chronic HBV infection and regulates their function
- DNA demethylation in PD-1 gene promoter induced by 5-azacytidine activates PD-1 expression on Molt-4 cells.
- Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum
- The co-inhibitory pathway and cellular immune imbalance in the progress of HBV infection
- Regulation of B7-H1 expression on peripheral monocytes and IFN-γ secretion in T lymphocytes by HBeAg.
- Clonal Expansions of CD8+ T Cells with IL-10 Secreting Capacity Occur during Chronic Mycobacterium tuberculosis Infection
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