Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
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Summary
It is shown that a single allele of oncogenic NrasG12D increases HSC proliferation but also increases reconstituting and self-renewal potential upon serial transplantation in irradiated mice, all prior to leukaemia initiation.
- Type
- article
- Published
- 2013-11-27
- Cited by
- 110
- References
- 51
- OpenAlex
- https://openalex.org/W1972903141
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4446795
Keywords
Stem cell, Sustainability, Neuroblastoma RAS viral oncogene homolog, Cell biology, Biology
References
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- Negative Regulators of Cytokine Signaling
- Constitutional NRAS mutations are rare among patients with Noonan syndrome or juvenile myelomonocytic leukemia
- Targeting oncogenic Ras signaling in hematologic malignancies.
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- Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
- Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.
Cited by
- Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities
- Oncogene Function in Pre-Leukemia Stage ofINV(16) Acute Myeloid Leukemia: A Dissertation
- Oncogenic K-Ras Promotes Proliferation in Quiescent Intestinal Stem Cells
- K-Ras, but Not H-Ras or N-Ras, Hyperactivation Regulates Brain Neural Stem Cell Proliferation in a Raf/Rb-dependent Manner
- Cancer Dormancy: A Regulatory Role for Endogenous Immunity in Establishing and Maintaining the Tumor Dormant State
- Inhibition of STAT5: A therapeutic option in BCR-ABL1-driven leukemia
- Activated K-Ras, But Not H-Ras or N-Ras, Regulates Brain Neural Stem Cell Proliferation in a Raf/Rb-Dependent Manner
- Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice*
- p38 links RAS to GATA2
- Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia.
- NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.
- Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T cell acute lymphoblastic leukemia
- Stem cell dynamics in homeostasis and cancer of the intestine
- Speeding to pluripotency.
- Cancer Stem Cell Immunology: Key to Understanding Tumorigenesis and Tumor Immune Escape?
- Stem cells: Competitive behaviour of cancer mutations
- Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies
- Stem cells: Competitive behaviour of cancer mutations
- Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting
- Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration
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