Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities
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Summary
Recent insights into the cellular and molecular determinants of the normal HSC niche are reviewed and how genetic changes in stromal cells and leukemia-induced BM niche remodeling contribute to blood malignancies are described.
- Type
- article
- Published
- 2015-03-05
- Cited by
- 408
- References
- 118
- Access
- Open access
- OpenAlex
- https://openalex.org/W25748932
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5415832
Keywords
Physics, Humanities, Forestry, Geography, Philosophy
References
- Stromal abnormalities in neoplastic bone marrow diseases
- CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
- The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche.
- Stromal-derived factor-1 deficiency in the bone marrow of acute myeloid leukemia
- Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells
- Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells
- Myelofibrosis in chronic myeloproliferative disorders--dynamics and clinical impact.
- Bone marrow stem cells: current and emerging concepts
- The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
- Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia
- Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells
- Stem cell gene expression programs influence clinical outcome in human leukemia
- Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
- Identification and Specification of the Mouse Skeletal Stem Cell
- Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
- IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development
- Identification of the haematopoietic stem cell niche and control of the niche size
- Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib
- Targeting of CD44 eradicates human acute myeloid leukemic stem cells
- Mimicking the functional hematopoietic stem cell niche in vitro: recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of mesenchymal stromal cells
Cited by
- The Hematopoietic Niche in Myeloproliferative Neoplasms
- Endothelial‐to‐hematopoietic transition: Notch‐ing vessels into blood
- Mesenchymal Stem Cells in Fibrotic Disease.
- Exosome-mediated microenvironment dysregulation in leukemia.
- Application of single-cell genomics in cancer: promise and challenges
- Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms
- Niche signaling promotes stem cell survival in the Drosophila testis via the Jak-STAT target DIAP1
- Communication of bone cells with hematopoiesis, immunity and energy metabolism.
- Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
- Bioengineering Hematopoietic Stem Cell Niche toward Regenerative Medicine.
- Regulation of hematopoietic stem cells in the niche
- The human and murine hematopoietic stem cell niches: are they comparable?
- Characterization and targeting of neoplastic stem cells in Ph+ chronic myeloid leukemia
- Regulatory role of Megakaryocytes on Hematopoietic Stem Cells Quiescence by CXCL4/PF4 in Bone Marrow Niche.
- The ability of multipotent mesenchymal stromal cells from the bone marrow of patients with leukemia to maintain normal hematopoietic progenitor cells
- Therapeutically targeting SELF‐reinforcing leukemic niches in acute myeloid leukemia: A worthy endeavor?
- Unraveling mechanisms of mesenchymal stromal cell–mediated immunomodulation through patient monitoring and product characterization
- Hypoxia and Hypoxia-Inducible Factors in Leukemias
- Dual effect of LPS on murine myeloid leukemia cells: Pro-proliferation and anti-proliferation.
- Caught in a Wnt storm: Complexities of Wnt signaling in hematopoiesis.
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