Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment
Explore this paper's citation graph
Summary
Kinetic studies support a model in which rapid dimer formation, catalyzed by PDI, occurs in the ER, and is followed by transport of dimers to a pre-Golgi compartment where the absence of PDI and a different lumenal environment allow the assembly process to be completed.
- Type
- article
- Published
- 1992-09-02
- Cited by
- 299
- References
- 81
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972480731
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6832886
Keywords
HBsAg, Brefeldin A, Chemistry, Secretion, Golgi apparatus
References
- Electron microscopy and immunoelectronmicroscopy of cytoplasmic hepatitis B antigen in hepatocytes.
- Evidence that luminal ER proteins are sorted from secreted proteins in a post‐ER compartment.
- Disulfide bond formation in proteins.
- Temperature and energy dependence of secretory protein transport in the exocrine pancreas.
- ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).
- Post-translational protein modification in the endoplasmic reticulum. Demonstration of fatty acylase and deoxymannojirimycin-sensitive alpha-mannosidase activities.
- Biosynthesis of the mannose 6-phosphate recognition marker in transport-impaired mouse lymphoma cells. Demonstration of a two-step phosphorylation.
- Antigenicity of reduced and alkylated Australia antigen.
- Biophysical and Biochemical Heterogeneity of Purified Hepatitis B Antigen
- Hepatitis B virus envelope L protein particles. Synthesis and assembly in Saccharomyces cerevisiae, purification and characterization.
- Intracellular assembly and packaging of hepatitis B surface antigen particles occur in the endoplasmic reticulum
- Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.
- Structure and assembly of the endoplasmic reticulum. The synthesis of three major endoplasmic reticulum proteins during lipopolysaccharide-induced differentiation of murine lymphocytes.
- A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures.
- Palmitylation of viral membrane glycoproteins takes place after exit from the endoplasmic reticulum.
- Reduction and Reoxidation of Australia Antigen: Loss and Reconstitution of Particle Structure and Antigenicity
- Distribution of the intermediate elements operating in ER to Golgi transport.
- Plasmid-directed synthesis of hepatitis B surface antigen in monkey cells
- Endoplasmin is a reticuloplasmin.
- Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region
Cited by
- Hepatitis B virus assembly is sensitive to changes in the cytosolic S loop of the envelope proteins.
- Techniques to dissect cellular and subcellular function in the Drosophila nervous system.
- Development and characterization of a 293 cell line with regulatable expression of the hepatitis B virus large envelope protein.
- St, a Truncated Envelope Protein Derived from the S Protein of Duck Hepatitis B Virus, Acts as a Chaperone for the Folding of the Large Envelope Protein
- The role of the HBV envelope proteins in the HDV replication cycle.
- Gene transcription acceleration: main cause of hepatitis B surface antigen production improvement by dimethyl sulfoxide in the culture of Chinese hamster ovary cells
- Cholesterol Depletion of Hepatoma Cells Impairs Hepatitis B Virus Envelopment by Altering the Topology of the Large Envelope Protein
- HBV Life Cycle: Entry and Morphogenesis
- A rational approach to the development of future generation processes for lipoprotein VLP vaccine candidates
- Hepatitis B virus morphogenesis.
- Gene expression profiling of human lipoprotein-loaded macrophages and atherosclerotic lesions with special emphasis on ADAMs
- Lipid foulant interactions during the chromatographic purification of virus-like particles from Saccharomyces cerevisiae
- Eignung von transgenen Pflanzen zur Produktion von oralen Vakzinen
- Monolith absorbants as a capture step for virus-like particles
- Variabilité génétique du virus de l'hépatite B et implication sur le diagnostic et la pathogénèse
- Structure and Physics of Viruses
- Evaluation of Aspergillus as a host for the production of viral proteins using hepatitis B as a model
- Functional Analysis of Hepatitis B Virus Variants with Mutations in the Envelope Proteins
- Determining and utilizing the quasispecies of the hepatitis B virus in clinical applications
- Trans-activation of cellular genes by hepatitis B virus proteins: a possible mechanism of hepatocarcinogenesis.
Related papers
- A peripheral protein associated with the cis-Golgi network redistributes in the intermediate compartment upon brefeldin A treatment
- Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action
- cis-Golgi proteins accumulate near the ER exit sites and act as the scaffold for Golgi regeneration after brefeldin A treatment in tobacco BY-2 cells
- Redistribution of a Golgi glycoprotein in plant cells treated with Brefeldin A
- Reversible dissociation of the plant golgi apparatus by brefeldin A
- Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER
- NSF is required for the brefeldin A‐promoted disassembly of the Golgi apparatus
- Live-Cell Imaging of Dual-Labeled Golgi Stacks in Tobacco BY-2 Cells Reveals Similar Behaviors for Different Cisternae during Movement and Brefeldin A Treatment
- Effects of brefeldin-A on Golgi morphology in human cultured fibroblasts observed in three-dimensional stereo scanning electron microscopy.